ArticlePrzeglad gastroenterologiczny2016
Expression of CD117, DOG-1, and IGF-1R in gastrointestinal stromal tumours - an analysis of 70 cases from 2004 to 2010.
Article in Przeglad gastroenterologiczny, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Evaluating boron neutron capture therapy as a potential treatment for unresectable gastrointestinal stromal tumors.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025Article
- Pembrolizumab combined with surgical treatment for spontaneously ruptured undifferentiated pleomorphic sarcoma of the liver: a case report and literature review.Frontiers in immunology · 2025Review
- Gastrointestinal stromal tumor with small cell carcinoma infiltration: a case report.Frontiers in oncology · 2024Article
- Intelligent identification system of gastric stromal tumors based on blood biopsy indicators.BMC medical informatics and decision making · 2023Article
- Precision Oncology in Gastrointestinal Stromal Tumors.Current oncology (Toronto, Ont.) · 2023Review
- DOG1 overexpression is associated with mismatch repair deficiency and BRAF mutations but unrelated to cancer progression in colorectal cancer.Histology and histopathology · 2022Article
- A rare case of omental extra-gastrointestinal stromal tumor showing two coexisting mutations on exon 14 of the PDGFRA gene.Gastroenterology report · 2021Article
- Evaluation of risk classifications for gastrointestinal stromal tumor using multi-parameter Magnetic Resonance analysis.Abdominal radiology (New York) · 2021Article
- Small Bowel Intussusception Due to Rare Cardiac Intimal Sarcoma Metastasis: A Case Report.Frontiers in surgery · 2021Article
- Gastrointestinal stromal tumors: a comprehensive review.Journal of gastrointestinal oncology · 2019Review
- A giant jejunal gastrointestinal stromal tumor misconceived as pancreatic cystic neoplasm: A case report.International journal of surgery case reports · 2019Article
- A Rare Case of a Ruptured Metastatic Hepatic Lesion from a Jejunal Gastrointestinal Stromal Tumor (GIST) Treated by Arterial Embolization.The American journal of case reports · 2018Article
- Gene expression analyses determine two different subpopulations in KIT-negative GIST-like (KNGL) patients.Oncotarget · 2018Article
- Case of oesophageal gastrointestinal stromal tumour.Przeglad gastroenterologiczny · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDetermination of the type of mutations in gastrointestinal stromal tumours (GIST) plays a major role in assessing the risk of progression of the disease, and also allows determination of the clinical management and treatment. More accurate GIST diagnosis is possible by using simultaneously various types of antibodies to immunohistochemistry methods in routine procedures.
aimTo evaluate the expression of CD117, DOG-1, and IGF-1R in patients with gastrointestinal stromal tumours, and analysis of the impact of the examined protein expression on patient survival with emphasis on specific recognition and prognostication of these tumours. MATERIAL AND
methodsThe protein expression was analyzed in 70 patients who had undergone surgical treatment for mesenchymal tumours of the gastrointestinal tract, using the immunohistochemical method.
resultsPositive expression of CD117, DOG-1, and IGF1R included 95.71%, 88.57% and 11.43% of study GISTs, respectively. Statistical analysis showed positive significant correlation between DOG-1 expression and histological type of tumour (p = 0.024). Analysis of overall survival curves of 70 GIST patients according to expression of CD117, DOG-1, and IGF1R did not show a tendency towards longer survival of patients with positive expression (p > 0.05).
conclusionsPredictive factors determining the survival time of patients are strongly associated with morphological features of tumours. A thorough analysis of each case plays a key role in predicting survival time of patients and may be a clue in targeting the therapeutic procedure.
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