ReviewThe Journal of physiology2016
Pivotal role of α2 Na
Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph
Review in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06049641 (Hypertension in High School Students), which is not on this map. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hypertension in High School Students: Genetic and Environmental Factors
Who cites it
37 citing papers in PubMed, 60 citations in OpenAlex.
- Ouabain-induced hypertension in rats: Mechanisms, variability and translational implications.Experimental physiology · 2026Review
- Cytochrome c and Ouabain Binding Site of Na,K-ATPase.Cell biochemistry and biophysics · 2025Article
- Cardiac Glycosides: From Natural Defense Molecules to Emerging Therapeutic Agents.Biomolecules · 2025Review
- Na,K-ATPase mediated and cardiotonic induced signaling in health and disease.Frontiers in physiology · 2025Review
- Role of NaInternational journal of molecular sciences · 2024Review
- Sensational site: the sodium pump ouabain-binding site and its ligands.American journal of physiology. Cell physiology · 2024Review
- Effects of Renal Denervation on Ouabain-Induced Hypertension in Rats.International journal of hypertension · 2024Article
- The vascular Na,K-ATPase: clinical implications in stroke, migraine, and hypertension.Clinical science (London, England : 1979) · 2023Review
- Effects of renal denervation on endogenous ouabain in spontaneously hypertensive rats.Acta cirurgica brasileira · 2023Article
- Role of Translationally Controlled Tumor Protein (TCTP) in the Development of Hypertension and Related Diseases in Mouse Models.Biomedicines · 2022Review
- Short-Term Mild Hypoxia Modulates Na,K-ATPase to Maintain Membrane Electrogenesis in Rat Skeletal Muscle.International journal of molecular sciences · 2022Article
- Comprehensive analysis identified a reduction in ATP1A2 mediated by ARID3A in abdominal aortic aneurysm.Journal of cellular and molecular medicine · 2022Article
- Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension.Clinical science (London, England : 1979) · 2022Article
- The microtubule network enables Src kinase interaction with the Na,K-ATPase to generate CaFrontiers in physiology · 2022Article
- Regulation of Cardiac Contractility by the Alpha 2 Subunit of the NaFrontiers in physiology · 2022Review
- A real-time PCR method to genotype mutant mouse models with altered affinity for cardiotonic steroids on the Na,K-ATPase.PloS one · 2022Article
- Endogenous Mammalian Cardiotonic Steroids-A New Cardiovascular Risk Factor?-A Mini-Review.Life (Basel, Switzerland) · 2021Review
- Na,K-ATPase as a target for endogenous cardiotonic steroids: What's the evidence?Genes & diseases · 2021Review
- Chronic Ouabain Prevents Na,K-ATPase Dysfunction and Targets AMPK and IL-6 in Disused Rat Soleus Muscle.International journal of molecular sciences · 2021Article
- Ouabain-Induced Gene Expression Changes in Human iPSC-Derived Neuron Culture Expressing Dopamine and cAMP-Regulated Phosphoprotein 32 and GABA Receptors.Brain sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Mordecai P BlausteinDepartment of Physiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. mblaustein@som.umaryland.edu.
Ling ChenDepartment of Physiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
John M HamlynDepartment of Physiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Frans H H LeenenHypertension Unit, University of Ottawa Heart Institute, Ottawa, ON, Canada, K1Y 4W7.
Jerry B LingrelDepartment of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267-0524, USA.
W Gil WierDepartment of Physiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Jin ZhangDepartment of Physiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
University of Maryland, Baltimore · USUniversity of Cincinnati · USUniversity of Ottawa · CA
Funding
CALCIUM AND SODIUM TRANSPORT IN VASCULAR SMOOTH MUSCLER01HL045215 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI BLAUSTEIN, MORDECAI P, HAMLYN, JOHN · 1990 to 2012
$4.1MIsoform-specific roles of the Na,K-ATPase in skeletal muscleR01AR063710 · NIAMS · UNIVERSITY OF CINCINNATI · PI HEINY, JUDITH A, LINGREL, JERRY B · 2013 to 2017
$2.2MNa+/Ca2+ Exchanger type-1 in Arterial Contraction and Salt-induced HypertensionR01HL107654 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI WIER, WITHROW GIL · 2011 to 2015
$1.8MAlpha-2 Na+ Pumps, [Ca2+], Arterial Contraction & HypertensionR01HL107555 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI BLAUSTEIN, MORDECAI P · 2012 to 2015
$1.5MPhysiological Regulation of MLCK in Intact ArteriesR01HL091969 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI WIER, WITHROW GIL · 2010 to 2013
$1.5MDevelopment of RhoA Optical Sensor Mice for Novel Vascular Smooth Muscle StudiesR21OD018315 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI RIZZO, MEGAN A, WIER, WITHROW GIL · 2014 to 2015
$418kCIHR MOP-74432NHLBI NIH HHS R01 HL045215NHLBI NIH HHS R01 HL091969NHLBI NIH HHS R01 HL107555NHLBI NIH HHS R01 HL107654NIAMS NIH HHS R01 AR063710NIH HHS R21 OD018315
Abstract
Reduced smooth muscle (SM)-specific α2 Na
Indexed as
AngiotensinsAnimalsBinding SitesCardiotonic AgentsCardiovascular SystemHumansHypertensionOuabainSodium-Potassium-Exchanging ATPaseSympathetic Nervous SystemAngiotensinsCardiotonic AgentsOuabainSodium-Potassium-Exchanging ATPasearterycardiac hypertrophyheart failurehypertension
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT06049641ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.