ArticleThe Journal of physiology2016
Inhibitory masking controls the threshold sensitivity of retinal ganglion cells.
Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Gap junctions fine-tune ganglion cell signals to equalize response kinetics within a given electrically coupled array.iScience · 2024Article
- GABAergic Inhibition Controls Receptive Field Size, Sensitivity, and Contrast Preference of Direction Selective Retinal Ganglion Cells Near the Threshold of Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The mechanistic functional landscape of retinitis pigmentosa: a machine learning-driven approach to therapeutic target discovery.Journal of translational medicine · 2024Article
- Genetic elimination of rod/cone coupling reveals the contribution of the secondary rod pathway to the retinal output.Science advances · 2022Article
- Transient expression of a GABA receptor subunit during early development is critical for inhibitory synapse maturation and function.Current biology : CB · 2021Article
- GABAeLife · 2021Article
- Rod and Cone Connections With Bipolar Cells in the Rabbit Retina.Frontiers in cellular neuroscience · 2021Article
- The Effect of Low-Dose Atropine on Alpha Ganglion Cell Signaling in the Mouse Retina.Frontiers in cellular neuroscience · 2021Article
- Dual-Cell Patch-Clamp Recording Revealed a Mechanism for a Ribbon Synapse to Process Both Digital and Analog Inputs and Outputs.Frontiers in cellular neuroscience · 2021Article
- Article
- Increased Connexin36 Phosphorylation in AII Amacrine Cell Coupling of the Mouse Myopic Retina.Frontiers in cellular neuroscience · 2020Article
- Article
- Gap Junctions Contribute to Differential Light Adaptation across Direction-Selective Retinal Ganglion Cells.Neuron · 2018Article
- Processing of single-photon responses in the mammalian On and Off retinal pathways at the sensitivity limit of vision.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Classification of Mouse Retinal Bipolar Cells: Type-Specific Connectivity with Special Reference to Rod-Driven AII Amacrine Pathways.Frontiers in neuroanatomy · 2017Article
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Authors and funding
9 authors.
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Abstract
key pointsRetinal ganglion cells (RGCs) in dark-adapted retinas show a range of threshold sensitivities spanning ∼3 log units of illuminance. Here, we show that the different threshold sensitivities of RGCs reflect an inhibitory mechanism that masks inputs from certain rod pathways. The masking inhibition is subserved by GABA ABSTRACT: The responses of rod photoreceptors, which subserve dim light vision, are carried through the retina by three independent pathways. These pathways carry signals with largely different sensitivities. Retinal ganglion cells (RGCs), the output neurons of the retina, show a wide range of sensitivities in the same dark-adapted conditions, suggesting a divergence of the rod pathways. However, this organization is not supported by the known synaptic morphology of the retina. Here, we tested an alternative idea that the rod pathways converge onto single RGCs, but inhibitory circuits selectively mask signals so that one pathway predominates. Indeed, we found that application of GABA receptor blockers increased the sensitivity of most RGCs by unmasking rod signals, which were suppressed. Our results indicate that inhibition controls the threshold responses of RGCs under dim ambient light. This mechanism can ensure that appropriate signals cross the bottleneck of the optic nerve in changing stimulus conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.