Evidence map›Paper›PMID 27350396›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2016

Effect of tumor dose, volume and overall treatment time on local control after radiochemotherapy including MRI guided brachytherapy of locally advanced cervical cancer.

Kari Tanderup, Lars Ulrik Fokdal, Alina Sturdza, Christine Haie-Meder, Renaud Mazeron, Erik van Limbergen, Ina Jürgenliemk-Schulz, Primoz Petric, Peter Hoskin, Wolfgang Dörr and 4 more

Erratum issuedAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 152 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Spanish Society for Radiation Oncology and Spanish Society of Medical Physicists recommendations on reirradiation in gynecological cancer: reirradiation techniques, survival outcomes, dose, and toxicity.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Guideline
  2. Pooled it
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92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Kari TanderupDepartment of Oncology, Aarhus University Hospital, Denmark. Electronic address: karitand@rm.dk.
Lars Ulrik FokdalDepartment of Oncology, Aarhus University Hospital, Denmark.
Alina SturdzaDepartment of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna, Austria.
Christine Haie-MederRadiation Oncology Department, Gustave Roussy Cancer Campus Grand Paris, Villejuif, France.
Renaud MazeronRadiation Oncology Department, Gustave Roussy Cancer Campus Grand Paris, Villejuif, France.
Erik van LimbergenDepartment of Radiation-Oncology, University Hospitals of Leuven, Belgium.
Ina Jürgenliemk-SchulzDepartment of Radiotherapy, University Medical Center Utrecht, The Netherlands.
Primoz PetricDepartment of Radiation Oncology, National Center for Cancer Care and Research, Doha, Qatar; Division of Radiotherapy, National Institute of Oncology, Ljubljana, Slovenia.
Peter HoskinMount Vernon Cancer Centre, Northwood, United Kingdom.
Wolfgang DörrDepartment of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna, Austria.
Søren M BentzenGreenebaum Cancer Center and Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA.
Christian KirisitsDepartment of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna, Austria.
Jacob Christian LindegaardDepartment of Oncology, Aarhus University Hospital, Denmark.
Richard PötterDepartment of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeCurrently, there is no consensus on dose prescription in image guided adaptive brachytherapy (IGABT) in locally advanced cervical cancer. The purpose of this study was to provide evidence based recommendations for tumor dose prescription based on results from a multi-center patient series (retroEMBRACE). MATERIALS AND

methodsThis study analyzed 488 locally advanced cervical cancer patients treated with external beam radiotherapy±chemotherapy combined with IGABT. Brachytherapy contouring and reporting was according to ICRU/GEC-ESTRO recommendations. The Cox Proportional Hazards model was applied to analyze the effect on local control of dose-volume metrics as well as overall treatment time (OTT), dose rate, chemotherapy, and tumor histology.

resultsWith a median follow up of 46months, 43 local failures were observed. Dose (D90) to the High Risk Clinical Target Volume (CTV

conclusionCTV

Indexed as

AdultAgedAged, 80 and overBrachytherapyChemoradiotherapyDose Fractionation, RadiationEvidence-Based MedicineFemaleHumansMagnetic Resonance ImagingMiddle AgedNeoplasm StagingRadiotherapy DosageRadiotherapy, Image-GuidedRadiotherapy Planning, Computer-AssistedTime FactorsCervical cancerDose effectImage guided brachytherapyLocal controlOverall treatment time

Identifiers

PMID27350396

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.