ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
Comprehensive investigation of aberrant microRNA profiling in bladder cancer tissues.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- circRNA CRIM1 regulates the migration and invasion of bladder cancer by targeting miR182/Foxo3a axis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022Article
- Prognostic Implication of a Cuproptosis-Related miRNA Signature in Hepatocellular Carcinoma.Journal of healthcare engineering · 2022Article
- Long non-coding RNA OTUD6B-AS1 overexpression inhibits the proliferation, invasion and migration of colorectal cancer cells via downregulation of microRNA-3171.Oncology letters · 2021Article
- MiR-182-5p and its target HOXA9 in non-small cell lung cancer: a clinical and in-silico exploration with the combination of RT-qPCR, miRNA-seq and miRNA-chip.BMC medical genomics · 2020Article
- Deciphering of Key Pharmacological Pathways of Poria Cocos Intervention in Breast Cancer Based on Integrated Pharmacological Method.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- MicroRNA-935 acts as a prognostic marker and promotes cell proliferation, migration, and invasion in colorectal cancer.Cancer biomarkers : section A of Disease markers · 2019Article
- IL-27 inhibits non-small-cell lung cancer cell metastasis by miR-935 in vitro.OncoTargets and therapy · 2019Article
- Molecular network-based identification of competing endogenous RNAs in bladder cancer.PloS one · 2019Article
- Expression of miR-182 and Foxo3a in patients with bladder cancer correlate with prognosis.International journal of clinical and experimental pathology · 2019Article
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- MicroRNA-200c Inhibits Epithelial-Mesenchymal Transition by Targeting the BMI-1 Gene Through the Phospho-AKT Pathway in Endometrial Carcinoma Cells In Vitro.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Identification of microRNAs as potential biomarkers for lung adenocarcinoma using integrating genomics analysis.Oncotarget · 2017Article
- miR-133b, a particular member of myomiRs, coming into playing its unique pathological role in human cancer.Oncotarget · 2017Review
- Circulating miRNA-21-5p as a diagnostic biomarker for pancreatic cancer: evidence from comprehensive miRNA expression profiling analysis and clinical validation.Scientific reports · 2017Article
- Dysregulation of miRNAs in bladder cancer: altered expression with aberrant biogenesis procedure.Oncotarget · 2017Review
- A comprehensive insight into the clinicopathologic significance of miR-144-3p in hepatocellular carcinoma.OncoTargets and therapy · 2017Article
- Role of downregulated miR-133a-3p expression in bladder cancer: a bioinformatics study.OncoTargets and therapy · 2017Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been accumulative evidence that microRNAs (miRNAs) play essential roles in the tumorigenesis and progression of bladder cancer. However, individual studies and small sample size caused discrepant outcomes. Thus, the current study focused on a comprehensive profiling of all differentially expressed miRNAs in a total of 519 bladder cancer tissue samples, based on miRNA microarray data. Altogether, 11 prioritized miRNAs stated by 21 published microarray datasets, including five down-regulated (miR-133a-3p, miR-1-3p, miR-99a-5p, miR-490-5p, and miR-133b) and six up-regulated candidate miRNAs (miR-182-5p, miR-935, miR-518e-3p, miR-573, miR-100-3p, and miR-3171) were analyzed with vote-counting strategy and a Robust Rank Aggregation method. Subsequently, miRNA in silico target prediction and potential pathway enrichment analysis were performed to investigate the prospective molecular mechanism of miRNAs in the tumorigenesis of bladder cancer. We found that most of the relative pathways of the aberrantly expressed miRNAs found in the current study were closely correlated with different biological processes, cellular components, molecular functions, cancer pathogeneses, and some cell signalings, such as Wnt signaling, insulin/IGF, PI3 kinase, and FGF signaling pathways. Hence, a comprehensive overview on the miRNA expression pattern in bladder cancer tissues was gained by the current study. These miRNAs might be involved in the tumorigenesis and deterioration of bladder cancer.
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