ArticleThe Journal of comparative neurology2017
Developmental analysis of the dopamine-containing neurons of the Drosophila brain.
Article in The Journal of comparative neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- A pair of dopaminergic neurons DAN-c1 mediateeLife · 2025Article
- dVGLUT Is a Mediator of Sex Differences in Dopamine Neuron Mitochondrial Function Across Aging and in a Parkinson's Disease Model.Aging cell · 2025Article
- Synapse-specific catecholaminergic modulation of neuronal glutamate release.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Lineages to circuits: the developmental and evolutionary architecture of information channels into the central complex.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Review
- A STIM dependent dopamine-neuropeptide axis maintains the larval drive to feed and grow in Drosophila.PLoS genetics · 2023Article
- The matricellular protein Drosophila Cellular Communication Network Factor is required for synaptic transmission and female fertility.Genetics · 2023Article
- Article
- Active forgetting requires Sickie function in a dedicated dopamine circuit inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dopamine activity in projection neurons regulates short-lasting olfactory approach memory in Drosophila.The European journal of neuroscience · 2022Article
- Optogenetic and thermogenetic manipulation of defined neural circuits and behaviors inLearning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- The Role of the Dopamine Transporter in the Effects of Amphetamine on Sleep and Sleep Architecture in Drosophila.Neurochemical research · 2022Article
- Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration.Aging cell · 2021Article
- Dynamics of Whole-Genome Contacts of Nucleoli inCells · 2020Article
- Article
- Effects on Dopaminergic Neurons Are Secondary in COX-Deficient Locomotor Dysfunction in Drosophila.iScience · 2020Article
- A single-cell transcriptomic atlas of the adulteLife · 2020Article
- Article
- Modulated Expression of the Protein Kinase GSK3 in Motor and Dopaminergic Neurons Increases Female Lifespan inFrontiers in genetics · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
The Drosophila dopaminergic (DAergic) system consists of a relatively small number of neurons clustered throughout the brain and ventral nerve cord. Previous work shows that clusters of DA neurons innervate different brain compartments, which in part accounts for functional diversity of the DA system. We analyzed the association between DA neuron clusters and specific brain lineages, developmental and structural units of the Drosophila brain that provide a framework of connections that can be followed throughout development. The hatching larval brain contains six groups of primary DA neurons (born in the embryo), which we assign to six distinct lineages. We can show that all larval DA clusters persist into the adult brain. Some clusters increase in cell number during late larval stages, whereas others do not become DA positive until early pupa. Ablating neuroblasts with hydroxyurea (HU) prior to onset of larval proliferation (generates secondary neurons) confirms that these added DA clusters are primary neurons born in the embryo, rather than secondary neurons. A single cluster that becomes DA positive in the late pupa, PAM1/lineage DALcm1/2, forms part of a secondary lineage that can be ablated by larval HU application. By supplying lineage information for each DA cluster, our analysis promotes further developmental and functional analyses of this important system of neurons. J. Comp. Neurol. 525:363-379, 2017. © 2016 Wiley Periodicals, Inc.
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