ArticleRetrovirology2016
Innate immune defects in HIV permissive cell lines.
Article in Retrovirology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Gene modification: Exploring the potential in treating kidney diseases.Pharmacological research · 2026Review
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- Alternative polyadenylation upon CPSF6 knock-out enhances HIV-1 infection in primary T cells.PLoS pathogens · 2025Article
- SAMD9L inhibits flavivirus translation independently of its capacity to trigger innate immune response.PLoS pathogens · 2025Article
- Review
- Optimization of Bangladesh and Malaysian genotype recombinant reporter Nipah viruses for in vitro antiviral screening and in vivo disease modeling.Antiviral research · 2024Article
- Mechanisms and Delivery of tRNA Therapeutics.Chemical reviews · 2024Review
- Single-Cell Transcriptomics ofCells · 2023Review
- Fused in Liposarcoma Protein, a New Player in the Regulation of HIV-1 Transcription, Binds to Known and Newly Identified LTR G-Quadruplexes.ACS infectious diseases · 2022Article
- Virus-like Particles: Measures and Biological Functions.Viruses · 2022Review
- Rapid manufacturing of non-activated potent CAR T cells.Nature biomedical engineering · 2022Article
- Human Three Prime Repair Exonuclease 1 Promotes HIV-1 Integration by Preferentially Degrading Unprocessed Viral DNA.Journal of virology · 2021Article
- Viral vector platforms within the gene therapy landscape.Signal transduction and targeted therapy · 2021Review
- Article
- Fishing for newly synthesized proteins with phosphonate-handles.Nature communications · 2020Article
- Links between Nutrition, Infectious Diseases, and Microbiota: Emerging Technologies and Opportunities for Human-Focused Research.Nutrients · 2020Review
- Next-Generation Sequencing in a Direct Model of HIV Infection Reveals Important Parallels to and Differences fromJournal of virology · 2020Article
- Gastrointestinal organoid technology advances studies of enteric virus biology.PLoS pathogens · 2020Article
- Limitations of dual-fluorescent HIV reporter viruses in a model of pre-activation latency.Journal of the International AIDS Society · 2019Article
- Clinical use of lentiviral vectors.Leukemia · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundPrimary CD4+ T cells and cell lines differ in their permissiveness to HIV infection. Impaired innate immunity may contribute to this different phenotype.
findingsWe used transcriptome profiling of 1503 innate immunity genes in primary CD4+ T cells and permissive cell lines. Two clusters of differentially expressed genes were identified: a set of 249 genes that were highly expressed in primary cells and minimally expressed in cell lines and a set of 110 genes with the opposite pattern. Specific to HIV, HEK293T, Jurkat, SupT1 and CEM cell lines displayed unique patterns of downregulation of genes involved in viral sensing and restriction. Activation of primary CD4+ T cells resulted in reversal of the pattern of expression of those sets of innate immunity genes. Functional analysis of prototypical innate immunity pathways of permissive cell lines confirmed impaired responses identified in transcriptome analyses.
conclusionIntegrity of innate immunity genes and pathways needs to be considered in designing gain/loss functional genomic screens of viral infection.
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Registered trials
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