ArticleAmerican journal of industrial medicine2016
Mortality of lead smelter workers: A follow-up study with exposure assessment.
Article in American journal of industrial medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Toxic Metals and Chronic Kidney Disease: a Systematic Review of Recent Literature.Current environmental health reports · 2018Pooled it
- Amyotrophic Lateral Sclerosis and Occupational Exposures: A Systematic Literature Review and Meta-Analyses.International journal of environmental research and public health · 2018Pooled it
- Lead and cancer: a narrative review and risk of bias assessment (2003-2020).Reviews on environmental health · 2026Review
- Environmental Pollution and Its Impact on Kidney Diseases: A Comprehensive Review of Current Evidence.Life (Basel, Switzerland) · 2026Review
- Exposure to Lead in Drinking Water Causes Cognitive Impairment via an Alzheimer's Disease Gene-Dependent Mechanism in Adult Mice.Journal of Alzheimer's disease : JAD · 2024Article
- Chronic Exposure to Lead and Cadmium in Residents Living Near a Zinc Smelter.International journal of environmental research and public health · 2021Article
- Developing a Health Impact Model for Adult Lead Exposure and Cardiovascular Disease Mortality.Environmental health perspectives · 2020Article
- Glycine supplementation mitigates lead-induced renal injury in mice.Journal of experimental pharmacology · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundLead exposure has been linked to impaired renal function and kidney failure. High lead exposures have been associated with increased mortality from certain cancers, hypertension, cardiovascular disease, and amyotrophic lateral sclerosis (ALS).
methodsWe extended vital status follow-up on a cohort of 1,990 lead smelter workers by 25 years and computed standardized mortality ratios and rate ratios (RR) stratified by cumulative lead exposure.
resultsThe update added 13,823 person-years at risk and 721 deaths. Increased risk of mortality was observed for the a priori outcomes of lung cancer, cardiovascular disease (including cerebrovascular disease), chronic kidney disease, and ALS. However, of these outcomes, only cardiovascular, cerebrovascular, and chronic kidney diseases were associated with a positive exposure-response in RR analyses.
conclusionsThis study reaffirms the association of lead exposure with cardiovascular and kidney diseases; however, increased mortality observed for certain cancers is not likely to be due to lead exposure. Am. J. Ind. Med. 59:979-986, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.