Evidence map›Paper›PMID 27349978›Full record

ReviewImmunotherapy2016

Checkpoint inhibitors for renal cell carcinoma: current landscape and future directions.

Matthew Zibelman, Pooja Ghatalia, Daniel M Geynisman, Elizabeth R Plimack

Open access · greenAbstract readReview
In one paragraph

Review in Immunotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Resistance to anticancer immunity in cancer patients: potential strategies to reverse resistance.Annals of oncology : official journal of the European Society for Medical Oncology · 2017
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Matthew ZibelmanDepartment of Medical Oncology, Fox Chase Cancer Center, Temple Health, 333 Cottman Avenue, Philadelphia, PA 19111, USA.
Pooja GhataliaTemple/Fox Chase Hematology Oncology Fellowship Program, Temple University School of Medicine, 3401 North Broad Street, Philadelphia, PA 19140, USA.
Daniel M GeynismanDepartment of Medical Oncology, Fox Chase Cancer Center, Temple Health, 333 Cottman Avenue, Philadelphia, PA 19111, USA.
Elizabeth R PlimackDepartment of Medical Oncology, Fox Chase Cancer Center, Temple Health, 333 Cottman Avenue, Philadelphia, PA 19111, USA.
Fox Chase Cancer Center · USTemple University · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
NCI NIH HHS P30 CA006927
6 · The paper itself

Abstract

Immunotherapy with checkpoint inhibitors has arrived and begun to change the landscape of clinical oncology, including for patients with renal cell carcinoma. Specifically, drugs targeting the programmed death 1 and cytotoxic T-lymphocyte associated antigen pathways have demonstrated remarkable responses for patients in clinical trials. In this article, we review the most recent available data for immune checkpoint inhibitors for patients with renal cell carcinoma. We discuss potential strategies for rational combination therapies in these patients, some of which are currently being studied, and address important future considerations for use of these novel agents in the years to come.

Indexed as

AnimalsAntibodies, MonoclonalAntineoplastic AgentsCarcinoma, Renal CellClinical Trials as TopicCombined Modality TherapyCTLA-4 AntigenHumansImmunotherapyProgrammed Cell Death 1 ReceptorAntibodies, MonoclonalAntineoplastic AgentsCTLA-4 AntigenPDCD1 protein, humanProgrammed Cell Death 1 Receptorcytokinecytotoxic T-lymphocyte associated protein 4immune checkpoint blockadeimmunotherapyprogrammed death 1renal cell carcinomaVEGF

Identifiers

PMID27349978
PMCPMC8819587
OpenAlexW2461826378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.