Evidence map›Paper›PMID 27349930›Full record

ArticleFEBS letters2016

Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development.

Hisayoshi Omori, Soichiro Ogaki, Daisuke Sakano, Mutsumi Sato, Kahoko Umeda, Naoki Takeda, Naomi Nakagata, Shoen Kume

Open access · hybridAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Hisayoshi OmoriInstitute of Molecular Embryology and Genetics, Kumamoto University, Japan.
Soichiro OgakiInstitute of Molecular Embryology and Genetics, Kumamoto University, Japan.
Daisuke SakanoInstitute of Molecular Embryology and Genetics, Kumamoto University, Japan.
Mutsumi SatoInstitute of Molecular Embryology and Genetics, Kumamoto University, Japan.
Kahoko UmedaInstitute of Molecular Embryology and Genetics, Kumamoto University, Japan.
Naoki TakedaDivision of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Japan.
Naomi NakagataDivision of Reproductive Engineering, Institute of Resource Development and Analysis, Kumamoto University, Japan.
Shoen KumeInstitute of Molecular Embryology and Genetics, Kumamoto University, Japan.
Kumamoto University · JPDepartment of Embryology · USTokyo Institute of Technology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

C2cd4c, encoded by a gene belonging to the C2cd4 family, contains a C2 domain conserved across species and is localized to the cytoplasm. To examine the role of C2cd4c in the pancreas, we studied its localization and generated C2cd4c knockout (KO) mice. C2cd4c was expressed in pancreatic endocrine progenitors at early embryonic stages. When endocrine cells arise from their precursors, C2cd4c is gradually confined to the insulin- and pancreatic polypeptide-expressing cells of the endocrine. In the adult pancreas, C2cd4c is restricted to the beta cells. C2cd4c KO mice showed normal embryonic pancreatic development and adult pancreatic function. Thus, our results suggest that C2cd4c is dispensable for pancreatic development.

Indexed as

AnimalsCalcium-Binding ProteinsCell DifferentiationCell LineageGene Expression Regulation, DevelopmentalInsulinInsulin-Secreting CellsIslets of LangerhansMembrane ProteinsMiceMice, KnockoutPancreasC2cd4c protein, mouseCalcium-Binding ProteinsInsulinMembrane ProteinsC2cd4insulinpancreaspancreatic beta cell

Identifiers

PMID27349930
PMCPMC5129588
OpenAlexW2460925733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.