ArticleHearing research2016
Prepulse inhibition of the acoustic startle reflex vs. auditory brainstem response for hearing assessment.
Article in Hearing research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Trial-by-trial auditory brainstem response detection.Scientific reports · 2026Article
- Characterizing behavioral effects of early-life stress in an animal model of auditory processing.Physiology & behavior · 2026Article
- Anxiety-like behavior in deaf Ebf1 conditional knockout mice.Hearing research · 2026Article
- CRISPR-free RNA base editing mediated PTC-readthrough restores hearing in mice with Otof nonsense mutation.Nature communications · 2025Article
- Hexahydrocannabinol: pharmacokinetics, systemic toxicity, and acute behavioral effects in Wistar rats.The international journal of neuropsychopharmacology · 2025Article
- Neural and behavioral binaural hearing impairment and its recovery following moderate noise exposure.Hearing research · 2025Article
- Early-Life Stress Impairs Perception and Neural Encoding of Rapid Signals in the Auditory Pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Universal automated classification of the acoustic startle reflex using machine learning.Hearing research · 2023Article
- Does insular cortex lesion cause tinnitus in rats?Iranian journal of basic medical sciences · 2022Article
- Prepulse inhibition predicts subjective hearing in rats.Scientific reports · 2021Article
- Automated classification of acoustic startle reflex waveforms in young CBA/CaJ mice using machine learning.Journal of neuroscience methods · 2020Article
- Gestational Stress Augments Postpartum β-Amyloid Pathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Vesicular Glutamatergic Transmission in Noise-Induced Loss and Repair of Cochlear Ribbon Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Alpha2B-Adrenergic Receptor Overexpression in the Brain Potentiate Air Pollution-induced Behavior and Blood Pressure Changes.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Big brown bats (Eptesicus fuscus) successfully navigate through clutter after exposure to intense band-limited sound.Scientific reports · 2018Article
- Spatial hearing ability of the pigmented Guinea pig (Cavia porcellus): Minimum audible angle and spatial release from masking in azimuth.Hearing research · 2018Article
- Addressing variability in the acoustic startle reflex for accurate gap detection assessment.Hearing research · 2018Article
- Kv3 KNeuropharmacology · 2018Article
- Brief Stimulus Exposure Fully Remediates Temporal Processing Deficits Induced by Early Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Reflex Modification Audiometry Reveals Dual Roles for Olivocochlear Neurotransmission.Frontiers in cellular neuroscience · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The high prevalence of noise-induced and age-related hearing loss in the general population has warranted the use of animal models to study the etiology of these pathologies. Quick and accurate auditory threshold determination is a prerequisite for experimental manipulations targeting hearing loss in animal models. The standard auditory brainstem response (ABR) measurement is fairly quick and translational across species, but is limited by the need for anesthesia and a lack of perceptual assessment. The goal of this study was to develop a new method of hearing assessment utilizing prepulse inhibition (PPI) of the acoustic startle reflex, a commonly used tool that measures detection thresholds in awake animals, and can be performed on multiple animals simultaneously. We found that in control mice PPI audiometric functions are similar to both ABR and traditional operant conditioning audiograms. The hearing thresholds assessed with PPI audiometry in sound exposed mice were also similar to those detected by ABR thresholds one day after exposure. However, three months after exposure PPI threshold shifts were still evident at and near the frequency of exposure whereas ABR thresholds recovered to the pre-exposed level. In contrast, PPI audiometry and ABR wave one amplitudes detected similar losses. PPI audiometry provides a high throughput automated behavioral screening tool of hearing in awake animals. Overall, PPI audiometry and ABR assessments of the auditory system are robust techniques with distinct advantages and limitations, which when combined, can provide ample information about the functionality of the auditory system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.