Evidence map›Paper›PMID 27349710›Full record

ReviewStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2016

Mesonephric adenocarcinoma of the vagina : Diagnosis and multimodal treatment of a rare tumor and analysis of worldwide experience.

Iris Mueller, Gerhard Kametriser, Volker R Jacobs, Gerhard Bogner, Alfons Staudach, Horst Koch, Pia Wolfrum-Ristau, Christiane Schausberger, Thorsten Fischer, Felix Sedlmayer

Open access · hybridAbstract readCase ReportsReview
In one paragraph

Review in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Mesonephric Adenocarcinoma of the Vagina HarboringDiagnostics (Basel, Switzerland) · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Iris MuellerDepartment of Obstetrics and Gynecology (OB/GYN), Paracelsus Medical University (PMU), Müllner Hauptstr. 48, 5020, Salzburg, Austria. i.haberlehner@salk.at.
Gerhard KametriserDepartment of Radiology and Radiation Oncology, Paracelsus Medical University (PMU), Müllner Hauptstrasse 48, 5020 Salzburg, Austria.
Volker R JacobsDepartment of Obstetrics and Gynecology (OB/GYN), Paracelsus Medical University (PMU), Müllner Hauptstr. 48, 5020, Salzburg, Austria.
Gerhard BognerDepartment of Obstetrics and Gynecology (OB/GYN), Paracelsus Medical University (PMU), Müllner Hauptstr. 48, 5020, Salzburg, Austria.
Alfons StaudachDepartment of Obstetrics and Gynecology (OB/GYN), Paracelsus Medical University (PMU), Müllner Hauptstr. 48, 5020, Salzburg, Austria.
Horst KochDepartment of Obstetrics and Gynecology (OB/GYN), Paracelsus Medical University (PMU), Müllner Hauptstr. 48, 5020, Salzburg, Austria.
Pia Wolfrum-RistauDepartment of Obstetrics and Gynecology (OB/GYN), Paracelsus Medical University (PMU), Müllner Hauptstr. 48, 5020, Salzburg, Austria.
Christiane SchausbergerDepartment of Obstetrics and Gynecology (OB/GYN), Paracelsus Medical University (PMU), Müllner Hauptstr. 48, 5020, Salzburg, Austria.
Thorsten FischerDepartment of Obstetrics and Gynecology (OB/GYN), Paracelsus Medical University (PMU), Müllner Hauptstr. 48, 5020, Salzburg, Austria.
Felix SedlmayerDepartment of Radiology and Radiation Oncology, Paracelsus Medical University (PMU), Müllner Hauptstrasse 48, 5020 Salzburg, Austria.
Paracelsus Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMesonephric adenocarcinoma of the vagina is an extremely rare tumor of the female genital tract, with only a few cases reported so far worldwide. Consequently, there is no established standard treatment and limited knowledge about the prognosis and biologic behavior of vaginal mesonephric adenocarcinoma.

methodsThis report documents a new case of vaginal mesonephric adenocarcinoma diagnosed in a 54-year-old woman, and analyzes this in the context of all previously published cases.

resultsMRI demonstrated that the 2.5 × 1.8 cm tumor of the vaginal wall was invading urethra and bladder. Following surgical excision, histologic analysis determined mesonephric adenocarcinoma of the vagina, stage pT2 R1. In order to avoid the mutilating extended surgery which would be required to reach R0 and considerable impairment of quality of life, adjuvant radiochemotherapy was administered with external radiation and brachytherapy, including 5 cycles of cisplatin (40 mg/m²) for radiosensitization. After 4 years of continuous oncologic follow-up, the patient is alive and clinically free of disease.

conclusionIn this case it was shown that adjuvant radiochemotherapy with radiation and brachytherapy was effective to manage the surgical R1 situation and maintain the patient's life quality. More published cases reports are needed to gradually substantiate optimal treatment strategies.

Indexed as

BrachytherapyChemoradiotherapyDose Fractionation, RadiationFemaleHumansMiddle AgedNeoplasm InvasivenessRadiotherapy, ConformalRare DiseasesTreatment OutcomeVaginal NeoplasmsWolffian DuctsBrachytherapyDiethylstilbestrolQuality of lifeRadiochemotherapyRadiotherapy

Identifiers

PMID27349710
PMCPMC4996863
OpenAlexW2467675444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.