Trial reportInternational journal of obesity (2005)2016
Higher resting-state activity in reward-related brain circuits in obese versus normal-weight females independent of food intake.
Trial report in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Neuroimaging Investigations of Obesity: a Review of the Treatment of Sex from 2010.Current obesity reports · 2023Pooled it
- Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals.Scientific reports · 2021Trial
- Machine learning-based identification of abnormal functional connectivity in obesity across different metabolic states.Communications medicine · 2026Article
- The Interplay Between Psychological and Neurobiological Predictors of Weight Regain: A Narrative Review.Nutrients · 2025Review
- How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings.Frontiers in aging neuroscience · 2025Review
- Obesity-related alterations of intrinsic functional architecture: a resting-state fMRI study based on the human connectome project.Frontiers in nutrition · 2025Article
- Association of body-mass index with physiological brain pulsations across adulthood - a fast fMRI study.International journal of obesity (2005) · 2024Article
- Relationship between functional connectivity and weight-gain risk of antipsychotics in schizophrenia.Schizophrenia research · 2024Article
- Metabolism-related brain morphology accelerates aging and predicts neurodegenerative diseases and stroke: a UK Biobank study.Translational psychiatry · 2023Article
- Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.Molecular psychiatry · 2023Review
- The body mass index is associated with increased temporal variability of functional connectivity in brain reward system.Frontiers in nutrition · 2023Article
- Effects of 12 weeks of aerobic exercise combined with resistance training on neurocognitive performance in obese women.Journal of exercise science and fitness · 2022Article
- Obesity and Cerebral Blood Flow in the Reward Circuitry of Youth With Bipolar Disorder.The international journal of neuropsychopharmacology · 2022Article
- Electroacupuncture enhances resting-state functional connectivity between dorsal caudate and precuneus and decreases associated leptin levels in overweight/obese subjects.Brain imaging and behavior · 2022Article
- Effects of bariatric surgery on functional connectivity of the reward and default mode network: A pre-registered analysis.Human brain mapping · 2021Article
- Exploration of the influence of body mass index on intra-network resting-state connectivity in chronic cigarette smokers.Drug and alcohol dependence · 2021Article
- Top-down control of conditioned overconsumption is mediated by insular cortex Nos1 neurons.Cell metabolism · 2021Article
- High body mass index, brain metabolism and connectivity: an unfavorable effect in elderly females.Aging · 2019Article
- Impact of Hunger, Satiety, and Oral Glucose on the Association Between Insulin and Resting-State Human Brain Activity.Frontiers in human neuroscience · 2019Article
- Sex Commonalities and Differences in Obesity-Related Alterations in Intrinsic Brain Activity and Connectivity.Obesity (Silver Spring, Md.) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn response to food cues, obese vs normal-weight individuals show greater activation in brain regions involved in the regulation of food intake under both fasted and sated conditions. Putative effects of obesity on task-independent low-frequency blood-oxygenation-level-dependent signals-that is, resting-state brain activity-in the context of food intake are, however, less well studied.
objectiveTo compare eyes closed, whole-brain low-frequency BOLD signals between severely obese and normal-weight females, as assessed by functional magnetic resonance imaging (fMRI).
methodsFractional amplitude of low-frequency fluctuations were measured in the morning following an overnight fast in 17 obese (age: 39±11 years, body mass index (BMI): 42.3±4.8 kg m
resultsCompared with normal-weight controls, obese females had increased low-frequency activity in clusters located in the putamen, claustrum and insula (P<0.05). This group difference was not altered by food intake. Self-reported hunger dropped and plasma glucose concentrations increased after food intake (P<0.05); however, these changes did not differ between the BMI groups.
conclusionReward-related brain regions are more active under resting-state conditions in obese than in normal-weight females. This difference was independent of food intake under the experimental settings applied in the current study. Future studies involving males and females, as well as utilizing repeated post-prandial resting-state fMRI scans and various types of meals are needed to further investigate how food intake alters resting-state brain activity in obese humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.