ArticleThe journal of headache and pain2016
Pain profiling of patients with temporomandibular joint arthralgia and osteoarthritis diagnosed with different imaging techniques.
Article in The journal of headache and pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Quantitative and qualitative assessment of sensory changes induced by local anesthetics block of two different trigeminal nerve branches.Clinical oral investigations · 2019Trial
- Pain levels and histological severity in a rat model of chemically-induced temporomandibular joint osteoarthritis.BMC oral health · 2026Article
- Prevalence of Osteoarthritis Using Cone Beam in Patients at the University of Cuenca.Clinical and experimental dental research · 2026Article
- Decoding adolescent TMJ osteoarthritis with multimodal machine learning.Journal of oral & facial pain and headache · 2026Article
- Pain modulation profiles in temporomandibular disorders with migraine and fibromyalgia.Journal of oral & facial pain and headache · 2026Article
- Clinical features and subgroup patterns in elderly and super-elderly TMD patients.Scientific reports · 2025Article
- Insomnia as a risk factor for temporomandibular disorders: a nationwide population-based cohort study.BMC oral health · 2025Article
- Temporomandibular Disorders in Brain Injury Patients and Diagnostic Accuracy of the Assessment Tools.Oral diseases · 2025Article
- Is Ultrasonography an Effective Method for Diagnosing Degenerative Changes in the Temporomandibular Joint?Biomedicines · 2024Article
- The Temporomandibular Joint and the Human Body: A New Perspective on Cross Talk.Dentistry journal · 2024Review
- Ultrasonographic examination of masticatory muscles in patients with TMJ arthralgia and headache attributed to temporomandibular disorders.Scientific reports · 2024Article
- Could painful temporomandibular disorders be nociplastic in nature? A critical review and new proposal.Acta odontologica Scandinavica · 2024Review
- The ultrasound assessment of osteoarthritis: the current status.Skeletal radiology · 2023Review
- The degeneration-pain relationship in the temporomandibular joint: Current understandings and rodent models.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Temporomandibular disorders cases with high-impact pain are more likely to experience short-term pain fluctuations.Scientific reports · 2022Article
- Temporal Summation and Aftersensations of Second Pain in Women with Myofascial Temporomandibular Disorder Differ by Presence of Temporomandibular Joint Pain.Journal of pain research · 2022Article
- Clinical variables associated with the presence of articular pain in patients with temporomandibular joint clicking.Clinical oral investigations · 2021Article
- Pain threshold and temporomandibular function in systemic sclerosis: comparison with psoriatic arthritis.Clinical rheumatology · 2018Article
- Pain Modulation: From Conditioned Pain Modulation to Placebo and Nocebo Effects in Experimental and Clinical Pain.International review of neurobiology · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical differentiation between pain mechanisms of temporomandibular joint (TMJ) arthralgia and osteoarthritis (OA) is challenging. The aims were to compare somatosensory function at the TMJs and conditioned pain modulation (CPM) effects between TMJ arthralgia and OA patients diagnosed clinically and based on different imaging techniques and age- and gender-matched healthy controls (n = 41).
methodsPatients (n = 58) underwent standard clinical examination and three different TMJ imaging modalities. After each examination, they were classified into arthralgia or OA based on the findings. TMJ region somatosensory testing was performed in all participants. Z-scores were calculated for patients based on healthy reference data. CPM was tested by comparing pressure pain thresholds (PPTs) at TMJ and thenar (control) before, during and after the application of painful and nonpainful cold stimuli. Data were analyzed using analyses of variance.
resultsSomatosensory abnormalities were commonly detected in both patient groups. Assessment of somatosensory function at the TMJ revealed that arthralgia patients were less sensitive to warmth, cold and tactile stimuli than OA patients (P < 0.048). OA patients showed pressure hyperalgesia compared with arthralgia patients (P = 0.025). There was a significant CPM effect at both test sites during painful cold application in all groups (P < 0.001). There was no significant difference in the relative CPM effect between groups except for clinically diagnosed arthralgia patients showing reduced CPM effect compared with controls (P = 0.047).
conclusionsPain profiles including somatosensory function differed between TMJ arthralgia and OA patients although CPM effects were similar in patients and controls. Thus, different TMJ pain conditions may share common pain mechanisms but the present study for the first time also indicated that differential pain mechanisms could be involved.
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