Evidence map›Paper›PMID 27349465›Full record

ReviewACS applied materials & interfaces2016

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances.

Mahdi Karimi, Parham Sahandi Zangabad, Alireza Ghasemi, Mohammad Amiri, Mohsen Bahrami, Hedieh Malekzad, Hadi Ghahramanzadeh Asl, Zahra Mahdieh, Mahnaz Bozorgomid, Amir Ghasemi and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ACS applied materials & interfaces, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed.

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  15. Recent advances and future challenges in nanosystems for ocular drug delivery.The Journal of pharmacology and experimental therapeutics · 2025
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75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mahdi KarimiWellman Center for Photomedicine, Massachusetts General Hospital , Boston, Massachusetts 02114, United States.
Parham Sahandi ZangabadResearch Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Science (TUOMS) , Tabriz, Iran.
Alireza GhasemiDepartment of Materials Science and Engineering, Sharif University of Technology , Azadi Avenue, 14588 Tehran, Iran.
Mohammad AmiriDepartment of Materials Science and Engineering, Sharif University of Technology , Azadi Avenue, 14588 Tehran, Iran.
Mohsen BahramiDepartment of Materials Science and Engineering, Sharif University of Technology , Azadi Avenue, 14588 Tehran, Iran.
Hedieh MalekzadDepartment of Chemistry, Kharazmi University of Tehran , Tehran, Iran.
Hadi Ghahramanzadeh AslDepartment of Materials Science and Engineering, Sharif University of Technology , Azadi Avenue, 14588 Tehran, Iran.
Zahra MahdiehDepartment of Biomedical and Pharmaceutical Sciences, Material Science and Engineering, University of Montana , Missoula, Montana 59812, United States.
Mahnaz BozorgomidDepartment of Applied Chemistry, Central Branch of Islamic Azad University of Tehran , Tehran, Iran.
Amir GhasemiDepartment of Materials Science and Engineering, Sharif University of Technology , Azadi Avenue, 14588 Tehran, Iran.
Mohammad Reza Rahmani Taji BoyukDepartment of Materials Science and Engineering, Sharif University of Technology , Azadi Avenue, 14588 Tehran, Iran.
Michael R HamblinWellman Center for Photomedicine, Massachusetts General Hospital , Boston, Massachusetts 02114, United States.

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
Synergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462k
NIAID NIH HHS R01 AI050875NIAID NIH HHS R21 AI121700
6 · The paper itself

Abstract

Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external stimulus when heat is applied from the outside, or can be internal when pathological lesions have a naturally elevated termperature. A low critical solution temperature (LCST) is a special feature of some polymeric materials, and most of the temperature-responsive nanocarriers have been designed based on this feature. In this review, we attempt to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications.

Indexed as

NanoparticlesDrug CarriersDrug Delivery SystemsPolymersTemperatureDrug CarriersPolymersanticancer deliverycharacterizationdual/multi responsivegene deliveryLCST/UCST behaviorsmart drug delivery systemssynthesistemperature-responsive nanocarriers

Identifiers

PMID27349465
PMCPMC5003094

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.