ArticleMolecular neurobiology2017
Network and Pathway-Based Analyses of Genes Associated with Parkinson's Disease.
Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- A Network and Pathway Analysis of Genes Associated With Atrial Fibrillation.Cardiovascular therapeutics · 2024Pooled it
- AWmeta Empowers Adaptively Weighted Transcriptomic Meta-Analysis.Current issues in molecular biology · 2026Article
- Repurposing the memory-promoting meclofenoxate hydrochloride as a treatment for Parkinson's disease through integrative multi-omics analysis.NPJ Parkinson's disease · 2025Article
- Using Computational Drug-Gene Analysis to Identify Novel Therapeutic Candidates for Retinal Neuroprotection.International journal of molecular sciences · 2022Article
- Investigation of CRS-associated cytokines in CAR-T therapy with meta-GNN and pathway crosstalk.BMC bioinformatics · 2022Article
- Comparative Transcriptome Analysis Provides Novel Molecular Events for the Differentiation and Maturation of Hepatocytes during the Liver Development of Zebrafish.Biomedicines · 2022Article
- Using Advanced Bioinformatics Tools to Identify Novel Therapeutic Candidates for Age-Related Macular Degeneration.Translational vision science & technology · 2022Article
- Huangqin Decoction Exerts Beneficial Effects on Rotenone-Induced Rat Model of Parkinson's Disease by Improving Mitochondrial Dysfunction and Alleviating Metabolic Abnormality of Mitochondria.Frontiers in aging neuroscience · 2022Article
- IL-17A and TNF-α inhibitors induce multiple molecular changes in psoriasis.Frontiers in immunology · 2022Article
- Integrated genomic, transcriptomic and metabolomic analysis reveals MDH2 mutation-induced metabolic disorder in recurrent focal segmental glomerulosclerosis.Frontiers in immunology · 2022Article
- Potential gene identification and pathway crosstalk analysis of age-related macular degeneration.Frontiers in genetics · 2022Article
- Characterizing the Expression Patterns of Parkinson's Disease Associated Genes.Frontiers in neuroscience · 2021Article
- MENDA: a comprehensive curated resource of metabolic characterization in depression.Briefings in bioinformatics · 2020Article
- Comprehensive gene and pathway analysis of cervical cancer progression.Oncology letters · 2020Article
- Transcriptomic Analysis Reveals Cu/Zn SODs Acting as Hub Genes of SODs inAntioxidants (Basel, Switzerland) · 2020Article
- Observational
- Identification of Candidate Genes Associated with Charcot-Marie-Tooth Disease by Network and Pathway Analysis.BioMed research international · 2020Article
- The core genes involved in the promotion of depression in patients with ovarian cancer.Oncology letters · 2019Article
- Pathway and network analysis of genes related to osteoporosis.Molecular medicine reports · 2019Article
- Bioinformatics prediction and analysis of hub genes and pathways of three types of gynecological cancer.Oncology letters · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) is a major neurodegenerative disease influenced by both genetic and environmental factors. Although previous studies have provided insights into the significant impacts of genetic factors on PD, the molecular mechanism underlying PD remains largely unclear. Under such situation, a comprehensive analysis focusing on biological function and interactions of PD-related genes will provide us valuable information to understand the pathogenesis of PD. In the current study, by reviewing the literatures deposited in PUBMED, we identified 242 genes genetically associated with PD, referred to as PD-related genes gene set (PDgset). Functional analysis revealed that biological processes and biochemical pathways related to neurodevelopment, metabolism, and immune system were enriched in PDgset. Then, pathway crosstalk analysis indicated that the enriched pathways could be grouped into two modules, with one module consisted of pathways mainly involved in neuronal signaling and another in immune response. Further, based on a global human interactome, we found that PDgset tended to have more moderate degree compared with cancer-related genes. Moreover, PD-specific molecular network was inferred using Steiner minimal tree algorithm and some potential related genes associated with PD were identified. In summary, by using network- and pathway-based methods to explore pathogenetic mechanism underlying PD, results from our work may have important implications for understanding the molecular mechanism underlying PD. Also, the framework proposed in our current work can be used to infer pathological molecular network and genes related to a specific disease.
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