ArticleNature communications2016
Memory of cell shape biases stochastic fate decision-making despite mitotic rounding.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Cellular Morphometric Analysis (CellMorph)-a comprehensive imaging-based tool for quantifying cellular phenotype heterogeneity and dynamics across biological processes.The FEBS journal · 2026Article
- Rax1/2 promote memory of growth by early Ras1 activation to maintain polarity across generations.bioRxiv : the preprint server for biology · 2025Article
- Interpretable Fine-Grained Phenotypes of Subcellular Dynamics via Unsupervised Deep Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Lifelike Transformative Materials for Biohybrid Implants: Inspired by Nature, Driven by Technology.Advanced healthcare materials · 2023Article
- Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Emerging machine learning approaches to phenotyping cellular motility and morphodynamics.Physical biology · 2021Review
- The Mechanics of Mitotic Cell Rounding.Frontiers in cell and developmental biology · 2020Review
- Zebrafish Klf4 maintains the ionocyte progenitor population by regulating epidermal stem cell proliferation and lateral inhibition.PLoS genetics · 2019Article
- Article
- Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis.Nature cell biology · 2018Article
- Modeling the Notch Response.Advances in experimental medicine and biology · 2018Review
- Virtual cardiac monolayers for electrical wave propagation.Scientific reports · 2017Article
- The temporal basis of angiogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.Developmental cell · 2017Review
- Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning.Developmental cell · 2017Article
- Shaping the cell fate.Cell cycle (Georgetown, Tex.) · 2017Article
- Physiological effects of a novel artificially synthesized antimalarial cyclic peptide: Mahafacyclin B.PloS one · 2017Article
- Real-time prediction of cell division timing in developing zebrafish embryo.Scientific reports · 2016Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell shape influences function, and the current model suggests that such shape effect is transient. However, cells dynamically change their shapes, thus, the critical question is whether shape information remains influential on future cell function even after the original shape is lost. We address this question by integrating experimental and computational approaches. Quantitative live imaging of asymmetric cell-fate decision-making and their live shape manipulation demonstrates that cellular eccentricity of progenitor cell indeed biases stochastic fate decisions of daughter cells despite mitotic rounding. Modelling and simulation indicates that polarized localization of Delta protein instructs by the progenitor eccentricity is an origin of the bias. Simulation with varying parameters predicts that diffusion rate and abundance of Delta molecules quantitatively influence the bias. These predictions are experimentally validated by physical and genetic methods, showing that cells exploit a mechanism reported herein to influence their future fates based on their past shape despite dynamic shape changes.
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