ArticleAnnals of surgery2017
Predicting Heterotopic Ossification Early After Burn Injuries: A Risk Scoring System.
Article in Annals of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Reduced Postburn Hypertrophic Scarring and Improved Physical Recovery With Yearlong Administration of Oxandrolone and Propranolol.Annals of surgery · 2018Trial
- Musculoskeletal Issues in Pediatric Burn Patients.Seminars in plastic surgery · 2024Review
- Physical and psychosocial outcomes among burn-injured people with heterotopic ossification: A burn model system study.Burns : journal of the International Society for Burn Injuries · 2024Article
- Heterotopic Ossification around the Elbow Revisited.Life (Basel, Switzerland) · 2023Review
- lncRNA MEG3 Promotes Osteogenic Differentiation of Tendon Stem Cells Via the miR-129-5p/TCF4/β-Catenin Axis and thus Contributes to Trauma-Induced Heterotopic Ossification.Stem cell reviews and reports · 2023Article
- Development of a 30-Day Readmission Risk Calculator for the Inpatient Rehabilitation Setting.Journal of the American Medical Directors Association · 2022Article
- Predicting Depression and Posttraumatic Stress Symptoms Following Burn Injury: A Risk Scoring System.Journal of burn care & research : official publication of the American Burn Association · 2022Article
- Burn-induced heterotopic ossification from incidence to therapy: key signaling pathways underlying ectopic bone formation.Cellular & molecular biology letters · 2021Review
- "Living Well" After Burn Injury: Using Case Reports to Illustrate Significant Contributions From the Burn Model System Research Program.Journal of burn care & research : official publication of the American Burn Association · 2021Review
- Contracture Severity at Hospital Discharge in Children: A Burn Model System Database Study.Journal of burn care & research : official publication of the American Burn Association · 2021Article
- Investigation into Possible Association of Oxandrolone and Heterotopic Ossification Following Burn Injury.Journal of burn care & research : official publication of the American Burn Association · 2019Article
- A Comparison of Contracture Severity at Acute Discharge in Patients With and Without Heterotopic Ossification: A Burn Model System National Database Study.Journal of burn care & research : official publication of the American Burn Association · 2019Article
- Surgical treatment of postburn heterotopic ossification around the elbow: Three case reports.Medicine · 2019Article
- Review
- Heterotopic Ossification and Hypertrophic Scars.Clinics in plastic surgery · 2017Review
- Local influence of high molecular polyethylene particles on heterotopic ossification.Experimental and therapeutic medicine · 2017Article
- The development and impact of heterotopic ossification in burns: a review of four decades of research.Scars, burns & healingReview
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveThe purpose of this study is to develop a scoring system that stratifies burn patients at the time of hospital admission according to risk of developing heterotopic ossification (HO). SUMMARY OF BACKGROUND DATA: HO in burns is an uncommon but severely debilitating problem with a poorly understood mechanism and no fully effective prophylactic measures.
methodsData were obtained from the Burn Model System National Database from 1994 to 2010 (n = 3693). The primary outcome is diagnosis of HO at hospital discharge. Logistic regression analysis was used to determine significant demographic and medical predictors of HO. A risk scoring system was created in which point values were assigned to predictive factors and final risk score is correlated with the percent risk of developing HO. The model was internally and externally validated.
resultsThe mean age of the subjects is 42.5 ± 16.0 years, the mean total body surface area (TBSA) burned is 18.5 ± 16.4%, and the population is 74.9% male. TBSA and the need for grafting of the arm, head/neck, and trunk were significant predictors of HO development (P < 0.01). A 13-point risk scoring system was developed using these significant predictors. The model c-statistic is 0.92. The risk scoring system demonstrated evidence of internal and external validity. An online calculator was developed to facilitate translation of knowledge to practice and research.
conclusionsThis HO risk scoring system identifies high-risk burn patients suitable for diagnostic testing and interventional HO prophylaxis trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.