ArticlePLoS neglected tropical diseases2016
Accuracy of Mobile Phone and Handheld Light Microscopy for the Diagnosis of Schistosomiasis and Intestinal Protozoa Infections in Côte d'Ivoire.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Diagnostic accuracy of rapid and point-of-care tests forFrontiers in parasitology · 2026Pooled it
- NTDscope: A multi-contrast portable microscope for disease diagnosis.PLOS global public health · 2026Article
- Portable digital microscopy with point-of-care testing for low-cost and efficient prevalence surveys for schistosomiasis control.PLoS neglected tropical diseases · 2025Article
- Integrating Digital Health Innovations to Achieve Universal Health Coverage: Promoting Health Outcomes and Quality Through Global Public Health Equity.Healthcare (Basel, Switzerland) · 2025Review
- Rapid and Comprehensive Screening for Urogenital and Gastrointestinal Schistosomiasis with Handheld Digital Microscopy Combined with Circulating Cathodic Antigen Testing.The American journal of tropical medicine and hygiene · 2024Article
- Review
- Diagnosis of Human Trematode Infections.Advances in experimental medicine and biology · 2024Review
- Performance evaluation of the AiDx multi-diagnostic automated microscope for the detection of schistosomiasis in Abuja, Nigeria.Scientific reports · 2023Article
- Smartphone-based platforms implementing microfluidic detection with image-based artificial intelligence.Nature communications · 2023Review
- A review on innovative optical devices for the diagnosis of human soil-transmitted helminthiasis and schistosomiasis: from research and development to commercialization.Parasitology · 2023Review
- Utilization of accessible resources in the fabrication of an affordable, portable, high-resolution, 3D printed, digital microscope for Philippine diagnostic applications.PLOS global public health · 2023Article
- Performance Evaluation of the Schistoscope 5.0 for (Semi-)automated Digital Detection and Quantification of Schistosoma haematobium Eggs in Urine: A Field-based Study in Nigeria.The American journal of tropical medicine and hygiene · 2022Article
- A review on low-cost microscopes for Open Science.Microscopy research and technique · 2022Review
- Schistoscope: An Automated Microscope with Artificial Intelligence for Detection ofMicromachines · 2022Article
- Human-Device Interaction in the Life Science Laboratory.Advances in biochemical engineering/biotechnology · 2022Article
- State-of-the-Art Techniques for Diagnosis of Medical Parasites and Arthropods.Diagnostics (Basel, Switzerland) · 2021Review
- Imaging Africa: a strategic approach to optical microscopy training in Africa.Nature methods · 2021Article
- Design and Adoption of Low-Cost Point-of-Care Diagnostic Devices: Syrian Case.Micromachines · 2021Article
- Systematic Review and Meta-Analysis of the Diagnostic Accuracy of Mobile-Linked Point-of-Care Diagnostics in Sub-Saharan Africa.Diagnostics (Basel, Switzerland) · 2021Review
- Mobile health applications for disease screening and treatment support in low-and middle-income countries: A narrative review.Heliyon · 2021Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHandheld light microscopy using compact optics and mobile phones may improve the quality of health care in resource-constrained settings by enabling access to prompt and accurate diagnosis. METHODOLOGY: Laboratory technicians were trained to operate two handheld diagnostic devices (Newton Nm1 microscope and a clip-on version of the mobile phone-based CellScope). The accuracy of these devices was compared to conventional light microscopy for the diagnosis of Schistosoma haematobium, S. mansoni, and intestinal protozoa infection in a community-based survey in rural Côte d'Ivoire. One slide of 10 ml filtered urine and a single Kato-Katz thick smear from 226 individuals were subjected to the Newton Nm1 microscope and CellScope for detection of Schistosoma eggs and compared to conventional microscopy. Additionally, 121 sodium acetate-acetic acid-formalin (SAF)-fixed stool samples were examined by the Newton Nm1 microscope and compared to conventional microscopy for the diagnosis of intestinal protozoa. PRINCIPAL
findingsThe prevalence of S. haematobium, S. mansoni, Giardia intestinalis, and Entamoeba histolytica/E. dispar, as determined by conventional microscopy, was 39.8%, 5.3%, 20.7%, and 4.9%, respectively. The Newton Nm1 microscope had diagnostic sensitivities for S. mansoni and S. haematobium infection of 91.7% (95% confidence interval (CI) 59.8-99.6%) and 81.1% (95% CI 71.2-88.3%), respectively, and specificities of 99.5% (95% CI 97.0-100%) and 97.1% (95% CI 92.2-99.1%), respectively. The CellScope demonstrated sensitivities for S. mansoni and S. haematobium of 50.0% (95% CI 25.4-74.6%) and 35.6% (95% CI 25.9-46.4%), respectively, and specificities of 99.5% (95% CI 97.0-100%) and 100% (95% CI 86.7-100%), respectively. For G. intestinalis and E. histolytica/E. dispar, the Newton Nm1 microscope had sensitivity of 84.0% (95% CI 63.1-94.7%) and 83.3% (95% CI 36.5-99.1%), respectively, and 100% specificity. CONCLUSIONS/SIGNIFICANCE: Handheld diagnostic devices can be employed in community-based surveys in resource-constrained settings after minimal training of laboratory technicians to diagnose intestinal parasites.
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