Evidence map›Paper›PMID 27348576›Full record

ArticleNature materials2016

Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces.

Yuanwen Jiang, João L Carvalho-de-Souza, Raymond C S Wong, Zhiqiang Luo, Dieter Isheim, Xiaobing Zuo, Alan W Nicholls, Il Woong Jung, Jiping Yue, Di-Jia Liu and 9 more

Open access · greenAbstract read
In one paragraph

Article in Nature materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 164 citations in OpenAlex.

  1. Article
  2. Chemical heterogeneity for battery materials.Nature reviews. Chemistry · 2026
    Review
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  19. Principles and applications of sono-optogenetics.Advanced drug delivery reviews · 2023
    Review
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Yuanwen JiangDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA.
João L Carvalho-de-SouzaDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA.
Raymond C S WongThe James Franck Institute, The University of Chicago, Chicago, Illinois 60637, USA.
Zhiqiang LuoDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA.
Dieter IsheimDepartment of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA.ORCID 0000-0003-3310-8192
Xiaobing ZuoThe X-ray Science Division, Argonne National Laboratory, Argonne, Illinois 60439, USA.
Alan W NichollsThe Research Resources Center, University of Illinois at Chicago, Chicago, Illinois 60607, USA.
Il Woong JungThe Center for Nanoscale Materials, Argonne National Laboratory, Argonne, Illinois 60439, USA.
Jiping YueBen May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA.
Di-Jia LiuThe Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne, Illinois 60439, USA.
Yucai WangDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA.
Vincent De AndradeThe X-ray Science Division, Argonne National Laboratory, Argonne, Illinois 60439, USA.
Xianghui XiaoThe X-ray Science Division, Argonne National Laboratory, Argonne, Illinois 60439, USA.
Luizetta NavrazhnykhDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA.
Dara E WeissDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA.
Xiaoyang WuBen May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA.
David N SeidmanDepartment of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA.
Francisco BezanillaDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA.
Bozhi TianDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA.
University of Chicago · USArgonne National Laboratory · USNorthwestern University · USUniversity of Illinois Chicago · US

Funding

The Electrophysiological Studies of Voltage Gated ChannelsR01GM030376 · NIGMS · UNIVERSITY OF CHICAGO · PI BEZANILLA, FRANCISCO J · 1985 to 2025
$9.1M
ELECTROPHYSIOLOGICAL STUDIES OF VOLTAGE GATED CHANNELSR37GM030376 · NIGMS · UNIVERSITY OF CHICAGO · PI BEZANILLA, FRANCISCO J · 1999 to 2008
$3.7M
NIGMS NIH HHS R01 GM030376NIGMS NIH HHS R37 GM030376
6 · The paper itself

Abstract

Silicon-based materials have widespread application as biophysical tools and biomedical devices. Here we introduce a biocompatible and degradable mesostructured form of silicon with multi-scale structural and chemical heterogeneities. The material was synthesized using mesoporous silica as a template through a chemical vapour deposition process. It has an amorphous atomic structure, an ordered nanowire-based framework and random submicrometre voids, and shows an average Young's modulus that is 2-3 orders of magnitude smaller than that of single-crystalline silicon. In addition, we used the heterogeneous silicon mesostructures to design a lipid-bilayer-supported bioelectric interface that is remotely controlled and temporally transient, and that permits non-genetic and subcellular optical modulation of the electrophysiology dynamics in single dorsal root ganglia neurons. Our findings suggest that the biomimetic expansion of silicon into heterogeneous and deformable forms can open up opportunities in extracellular biomaterial or bioelectric systems.

Identifiers

PMID27348576
PMCPMC5388139
OpenAlexW2473757742

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.