Evidence map›Paper›PMID 27348211›Full record

Trial reportJournal of child and adolescent psychopharmacology2017

Risperidone Added to Psychostimulant in Children with Severe Aggression and Attention-Deficit/Hyperactivity Disorder: Lack of Effect on Attention and Short-Term Memory.

Cristan A Farmer, Jeffery N Epstein, Robert L Findling, Kenneth D Gadow, L Eugene Arnold, Heidi Kipp, David J Kolko, Eric Butter, Jayne Schneider, Oscar G Bukstein and 3 more

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of child and adolescent psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00796302 (Stimulant and Risperidone in Children With Severe Physical Aggression), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00796302 phase4completednot on this map

Stimulant and Risperidone in Children With Severe Physical Aggression

TypeinterventionalSponsorMichael AmanRan2008 to 2012Enrolled168ConditionsAttention Deficit Disorder With HyperactivityArmsMethylphenidate HCl, Risperidone, Parent Management Training (PMT), Placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Cristan A Farmer1 Nisonger Center, Ohio State University , Columbus, Ohio.
Jeffery N Epstein2 Department of Pediatrics, University of Cincinnati , Cincinnati, Ohio.
Robert L Findling3 Department of Psychiatry, Case Western Reserve University , Cleveland, Ohio.
Kenneth D Gadow4 Department of Psychiatry, Stony Brook University , Stony Brook, New York.
L Eugene Arnold1 Nisonger Center, Ohio State University , Columbus, Ohio.
Heidi Kipp5 Department of Psychiatry, University of Pittsburgh , Pittsburgh, Pennsylvania.
David J Kolko5 Department of Psychiatry, University of Pittsburgh , Pittsburgh, Pennsylvania.
Eric Butter1 Nisonger Center, Ohio State University , Columbus, Ohio.
Jayne Schneider4 Department of Psychiatry, Stony Brook University , Stony Brook, New York.
Oscar G Bukstein5 Department of Psychiatry, University of Pittsburgh , Pittsburgh, Pennsylvania.
Nora K McNamara3 Department of Psychiatry, Case Western Reserve University , Cleveland, Ohio.
Brooke S G Molina5 Department of Psychiatry, University of Pittsburgh , Pittsburgh, Pennsylvania.
Michael G Aman1 Nisonger Center, Ohio State University , Columbus, Ohio.
The Ohio State University Wexner Medical Center · USUniversity of Pittsburgh · USCase Western Reserve University · USStony Brook University · USUniversity of Cincinnati · US

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
World Trade Center Worker and Volunteer Medical Screening ProgramM01RR010710 · NCRR · STATE UNIVERSITY NEW YORK STONY BROOK · PI GOLDSTEIN, RITA Z · 1998 to 2009
$17.6M
The Ohio State University Center for Clinical and Translational Science (UL1)UL1TR000090 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2012 to 2013
$7.9M
1/4-Stimulant and Risperidone for Youth with Severe Physical AggressionR01MH077907 · NIMH · OHIO STATE UNIVERSITY · PI AMAN, MICHAEL GEORGE · 2008 to 2011
$1.9M
3/4-Stimulant and Risperidone for Youth with Severe Physical AggressionR01MH077750 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI MCNAMARA, NORA · 2008 to 2011
$1.6M
2/4-Stimulant and Risperidone for Youth with Severe Physical AggressionR01MH077676 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G. · 2008 to 2011
$1.6M
4/4-Stimulant and Risperidone for Youth with Severe Physical AggressionR01MH077997 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI GADOW, KENNETH D · 2008 to 2011
$1.5M
NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1 TR000090NCRR NIH HHS M01 RR010710NCRR NIH HHS UL1 RR024153NIMH NIH HHS R01 MH077676NIMH NIH HHS R01 MH077750NIMH NIH HHS R01 MH077907NIMH NIH HHS R01 MH077997
6 · The paper itself

Abstract

objectiveProfessionals have periodically expressed concern that atypical antipsychotics may cause cognitive blunting in treated patients. In this study, we report data from a double-blind, randomized, controlled study of stimulant plus placebo versus combined stimulant and risperidone to evaluate the effects of the atypical antipsychotic on attention and short-term memory.

methodsA total of 165 (n = 83 combined treatment; n = 82 stimulant plus placebo) children with attention-deficit/hyperactivity disorder and severe physical aggression, aged 6-12 years, were evaluated with Conners' Continuous Performance Test (CPT-II) and the Wechsler Intelligence Scale for Children-III (WISC) Digit Span subscale at baseline, after 3 weeks of stimulant-only treatment, and after six additional weeks of randomized treatment (stimulant+placebo vs. stimulant+risperidone).

resultsAt 3 weeks, improvement on CPT-II performance (Commissions and Reaction Time Standard Error; p < 0.001) and on Digit Span memory performance (p < 0.006) was noted for the full sample. At study week 9, no difference in CPT-II or Digit Span performance was observed between the randomized groups (ps = 0.41 to 0.83).

conclusionsSimilar to other studies, we found no deleterious effects on attention and short-term memory associated with short-term use of risperidone. NCT00796302.

Indexed as

AggressionAntipsychotic AgentsAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildDouble-Blind MethodDrug Therapy, CombinationFemaleHumansMaleMemory, Short-TermRisperidoneSeverity of Illness IndexAntipsychotic AgentsCentral Nervous System StimulantsRisperidoneattention-deficit/hyperactivity disorderCNS stimulantsconduct disorderoppositional defiant disorderRisperidone

Identifiers

PMID27348211
PMCPMC5367910
OpenAlexW2464372024

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.