Evidence map›Paper›PMID 27348008›Full record

ArticleMembranes2016

Biochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins.

Vitalii Silin, John J Kasianowicz, Ariel Michelman-Ribeiro, Rekha G Panchal, Sina Bavari, Joseph W F Robertson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Membranes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vitalii SilinPhysical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899-8120, USA. vitalii.silin@nist.gov.
John J KasianowiczPhysical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899-8120, USA. john.kasianowicz@nist.gov.
Ariel Michelman-RibeiroPhysical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899-8120, USA. lasirenita54@yahoo.com.
Rekha G PanchalUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702-5011, USA. rekha.g.panchal.civ@mail.mil.
Sina BavariUS Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702-5011, USA. sina.bavari.civ@mail.mil.
Joseph W F RobertsonPhysical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899-8120, USA. joseph.robertson@nist.gov.

Funding

An Integrated System for Single Molecule Electronic Sequencing by SynthesisR01HG007415 · NHGRI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHURCH, GEORGE M, JU, JINGYUE · 2013 to 2015
$5.2M
NHGRI NIH HHS R01 HG007415
6 · The paper itself

Abstract

Tethered lipid bilayer membranes (tBLMs) have been used in many applications, including biosensing and membrane protein structure studies. This report describes a biosensor for anthrax toxins that was fabricated through the self-assembly of a tBLM with B. anthracis protective antigen ion channels that are both the recognition element and electrochemical transducer. We characterize the sensor and its properties with electrochemical impedance spectroscopy and surface plasmon resonance. The sensor shows a sensitivity similar to ELISA and can also be used to rapidly screen for molecules that bind to the toxins and potentially inhibit their lethal effects.

Indexed as

anthraxbiochipedema factorlethal factorprotective antigenscreeningtethered bilayer membranetherapeutic agents

Identifiers

PMID27348008
PMCPMC5041027

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.