ArticleJournal of pediatric gastroenterology and nutrition2016
Environmental Enteric Dysfunction Is Associated With Poor Linear Growth and Can Be Identified by Host Fecal mRNAs.
Article in Journal of pediatric gastroenterology and nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Environmental enteric dysfunction pathways and child stunting: A systematic review.PLoS neglected tropical diseases · 2018Pooled it
- Exposure to Animal Feces and Human Health: A Systematic Review and Proposed Research Priorities.Environmental science & technology · 2017Pooled it
- Complementary feeding with cowpea reduces growth faltering in rural Malawian infants: a blind, randomized controlled clinical trial.The American journal of clinical nutrition · 2017Trial
- Trial
- Perspective: Connecting the dots between domestic livestock ownership and child linear growth in low- and middle-income countries.Maternal & child nutrition · 2024Article
- Factors associated with stunting in under-five children with environmental enteropathy in slum areas of Jimma town, Ethiopia.Frontiers in nutrition · 2024Article
- Environmental enteric dysfunction: gut and microbiota adaptation in pregnancy and infancy.Nature reviews. Gastroenterology & hepatology · 2023Review
- Impact of childhood malnutrition and intestinal microbiota on MDR infections.JAC-antimicrobial resistance · 2023Review
- Stool biomarkers as measures of enteric pathogen infection in infants from Addis Ababa informal settlements.PLoS neglected tropical diseases · 2023Article
- Environmental enteropathy and its association with water sanitation and hygiene in slum areas of Jimma Town Ethiopia.PloS one · 2023Article
- Unravelling the reservoirs for colonisation of infants withBMJ open · 2022Article
- Choline, DHA, and Diarrheal Disease Associated with Growth Faltering in a Case-Control Study.Current developments in nutrition · 2022Article
- Biomarkers of environmental enteric dysfunction are differently associated with recovery and growth among children with moderate acute malnutrition in Sierra Leone.The American journal of clinical nutrition · 2021Article
- Biomarkers of environmental enteric dysfunction are not consistently associated with linear growth velocity in rural Zimbabwean infants.The American journal of clinical nutrition · 2021Article
- A One Health Approach to Child Stunting: Evidence and Research Agenda.The American journal of tropical medicine and hygiene · 2021Review
- A novel histological index for evaluation of environmental enteric dysfunction identifies geographic-specific features of enteropathy among children with suboptimal growth.PLoS neglected tropical diseases · 2020Article
- Environmental enteric dysfunction and child stunting.Nutrition reviews · 2019Review
- Detection and interpretation of fecal host mRNA in rural Malawian infants aged 6-12 months at risk for environmental enteric dysfunction.Experimental biology and medicine (Maywood, N.J.) · 2018Observational
- EB 2017 Article: Interpretation of the lactulose:mannitol test in rural Malawian children at risk for perturbations in intestinal permeability.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- Impact of Childhood Malnutrition on Host Defense and Infection.Clinical microbiology reviews · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveEnvironmental enteric dysfunction (EED) can be assessed by the lactulose:mannitol (L:M) test. Our objective was to determine if selected host fecal transcripts were correlated with EED, and whether transcripts and clinical characteristics could be used to predict EED in rural African children.
methodsDemographic and sanitation characteristics, along with L:M testing and host fecal transcript analyses from 798 asymptomatic Malawian children aged 12 to 61 months were compared with linear growth over the subsequent 3 months. Fecal host mRNA analysis included quantification of expression of 18 transcripts associated with L:M. Permeability was categorized as normal (L:M ≤ 0.15), moderate (0.15<L:M<0.45) and severe (L:M ≥ 0.45), and random forest predictive models were created.
resultsL:M was inversely correlated with linear growth over the subsequent 3 months (r = -0.32, P < 0.001) and severe EED was associated with stunting (P < 0.0001). Age younger than 24 months, weight-for-height z score <0, domesticated animals in the child's sleep environment, lack of a pit latrine combined with a potentially contaminated water source, and a recent history of diarrhea were associated with severe EED. A random forest model using CD53, HLA-DRA, MUC12, and TNF was 84% sensitive for severe EED and 83% sensitive for no EED.
conclusionsSelected host fecal transcripts can be used in a random forest model as a noninvasive biomarker for categories of EED in rural African children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.