Evidence map›Paper›PMID 27347560›Full record

ArticleInside the cell2016

Mitochondrial uncoupling proteins regulate angiotensin-converting enzyme expression: crosstalk between cellular and endocrine metabolic regulators suggested by RNA interference and genetic studies.

Sukhbir S Dhamrait, Cecilia Maubaret, Ulrik Pedersen-Bjergaard, David J Brull, Peter Gohlke, John R Payne, Michael World, Birger Thorsteinsson, Steve E Humphries, Hugh E Montgomery

Open access · hybridAbstract readDuplicate Publication
In one paragraph

Article in Inside the cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 5 countries.

Sukhbir S DhamraitCentre for Cardiovascular Genetics, BHF Laboratories University College London London UK; Department of Cardiology Western Sussex Hospitals NHS Trust West Sussex UK.
Cecilia MaubaretCentre INSERM U897-Epidemiologie-Biostatistique Bordeaux France.
Ulrik Pedersen-BjergaardDepartment of Cardiology, Nephrology and Endocrinology Hillerød Hospital Hillerød Denmark; Faculty of Health Sciences University of Copenhagen Copenhagen Denmark.
David J BrullCentre for Cardiovascular Genetics, BHF Laboratories University College London London UK; Department of Cardiology The Whittington Hospital NHS Trust London UK.
Peter GohlkeInstitute of Experimental and Clinical Pharmacology University Hospital of Schleswig-Holstein Kiel Germany.
John R PayneCentre for Cardiovascular Genetics, BHF Laboratories University College London London UK; Scottish National Advanced Heart Failure Service Golden Jubilee National Hospital Clydebank UK.
Michael WorldRoyal Centre for Defence Medicine Queen Elizabeth Hospital Birmingham UK.
Birger ThorsteinssonDepartment of Cardiology, Nephrology and Endocrinology Hillerød Hospital Hillerød Denmark; Faculty of Health Sciences University of Copenhagen Copenhagen Denmark.
Steve E HumphriesCentre for Cardiovascular Genetics, BHF Laboratories University College London London UK.
Hugh E MontgomeryUCL and National Centre for Sport, Exercise & Health University College London London UK; UCL Institute for Human Health and Performance University College London London UK.
University College London · GBUniversity of Copenhagen · DKBordeaux Population Health · FRGolden Jubilee National Hospital · GBQueen Elizabeth Hospital Birmingham · GBRF Laboratories (United States) · USUniversity Hospital Schleswig-Holstein · DEUniversity Hospitals Sussex NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uncoupling proteins (UCPs) regulate mitochondrial function, and thus cellular metabolism. Angiotensin-converting enzyme (ACE) is the central component of endocrine and local tissue renin-angiotensin systems (RAS), which also regulate diverse aspects of whole-body metabolism and mitochondrial function (partly through altering mitochondrial UCP expression). We show that ACE expression also appears to be

Indexed as

ACEassociation studiesendothelial cellgene expressiongeneticsuncoupling protein

Identifiers

PMID27347560
PMCPMC4915277
OpenAlexW1723399308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.