Prohibitin: an unexpected role in sex dimorphic functions.

K Hoa Nguyen, Sudharsana R Ande, Suresh Mishra

Abstract read

In one paragraph

Article in Biology of sex differences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Comparative Transcriptome Analyses ofFrontiers in microbiology · 2020
Article
Prohibitin: a potential therapeutic target in tyrosine kinase signaling.Signal transduction and targeted therapy
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

K Hoa Nguyen *Department of Internal Medicine, John Buhler Research Centre, University of Manitoba, Rm 843, 715 McDermot Avenue, Winnipeg, Manitoba R3E 3P4 Canada.

Sudharsana R Ande *Department of Internal Medicine, John Buhler Research Centre, University of Manitoba, Rm 843, 715 McDermot Avenue, Winnipeg, Manitoba R3E 3P4 Canada.

Suresh MishraDepartment of Internal Medicine, John Buhler Research Centre, University of Manitoba, Rm 843, 715 McDermot Avenue, Winnipeg, Manitoba R3E 3P4 Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sex differences are known to exist in adipose and immune functions in the body, and sex steroid hormones are known to be involved in sexually dimorphic biological and pathological processes related to adipose-immune interaction. However, our knowledge of proteins that mediate such differences is poor. Two novel obese mice models, Mito-Ob and m-Mito-Ob, that have been reported recently have revealed an unexpected role of a pleiotropic protein, prohibitin (PHB), in sex differences in adipose and immune functions. This discovery points towards a role of pleiotropic proteins and their potential interplay with sex steroid hormones in mediating sexually dimorphic adipose-immune interaction.

Indexed as

Adipose-immune interactionInflammationInsulin resistanceMetabolic dysregulationObesityPleiotropic proteins

Identifiers

PMID27347368

DOI10.1186/s13293-016-0083-9

PMCPMC4921003

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.