ArticleTherapeutic advances in chronic disease2016
Patient-reported functioning in major depressive disorder.
Article in Therapeutic advances in chronic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What Helps and Hinders Recovery from Depression? A Systematic Review and Qualitative Evidence Synthesis of Patient-Identified Recovery Factors.Psychotherapy and psychosomatics · 2026Pooled it
- The Effects of Adding Art Therapy to Ongoing Antidepressant Treatment in Moderate-to-Severe Major Depressive Disorder: A Randomized Controlled Study.International journal of environmental research and public health · 2022Trial
- Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study.Psychological medicine · 2025Article
- Prevalence and Impact of Antidepressant and Anti-Anxiety Use Among Saudi Medical Students: A National Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Optimizing the diagnosis and treatment of depression in primary care: the emerging role of vortioxetine treatment.Frontiers in psychiatry · 2025Article
- Effectiveness of vortioxetine in elderly patients with major depressive disorder in real-world clinical practice: Results from the RELIEVE study.Journal of psychopharmacology (Oxford, England) · 2024Observational
- Relationship between cognitive function and functional outcomes in remitted major depression.BMC psychiatry · 2024Article
- Review
- Effectiveness of Vortioxetine in Working Patients with Major Depressive Disorder in China: A Subgroup Analysis of the RELIEVE China Study.Neuropsychiatric disease and treatment · 2024Article
- Quality of Life and Functioning Impairments Across Psychiatric Disorders in Adults Presenting for Outpatient Psychiatric Evaluation and Treatment.Psychiatric research and clinical practice · 2024Article
- Effectiveness of Vortioxetine for the Treatment of Emotional Blunting in Patients with Major Depressive Disorder Experiencing Inadequate Response to SSRI/SNRI Monotherapy in Spain: Results from the COMPLETE Study.Neuropsychiatric disease and treatment · 2024Article
- Functional Impairment, Attachment, and Affective Temperaments in Euthymic Patients with Bipolar Disorder.Psychiatry and clinical psychopharmacology · 2023Article
- Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- In pursuit of full recovery in major depressive disorder.European archives of psychiatry and clinical neuroscience · 2023Article
- Observational
- Effectiveness of vortioxetine in patients with major depressive disorder and co-morbid generalized anxiety disorder in routine clinical practice: A subgroup analysis of the RELIEVE study.Journal of psychopharmacology (Oxford, England) · 2023Observational
- Real-world effectiveness of vortioxetine in outpatients with major depressive disorder: functioning and dose effects.BMC psychiatry · 2022Article
- The pattern glare and visual memory are disrupted in patients with major depressive disorder.BMC psychiatry · 2022Article
- Emotional blunting in patients with depression. Part II: relationship with functioning, well-being, and quality of life.Annals of general psychiatry · 2022Article
- Emotional blunting in patients with depression. Part I: clinical characteristics.Annals of general psychiatry · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivesCompared with the general population, patients with major depressive disorder (MDD) report substantial deficits in their functioning that often go beyond the clinical resolution of depressive symptoms. This study examines the impact of MDD and its treatment on functioning.
methodsFrom the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial, we analyzed complete data of 2280 adult outpatients with MDD at entry and exit points of each level of antidepressant treatment and again 12 months post treatment. Functioning was measured using the Work and Social Adjustment Scale (WSAS).
resultsThe results show that only 7% of patients with MDD reported within-normal functioning before treatment. The proportion of patients achieving within-normal functioning (WSAS) scores significantly increased after treatment. However, the majority of patients (>60%) were still in the abnormal range on functioning at exit. Although remitted patients had greater improvements compared with nonremitters, a moderate proportion of remitted patients continued to experience ongoing deficits in functioning after treatment (20-40%). Follow-up data show that the proportions of patients experiencing normal scores for functioning after 12 months significantly decreased from the end of treatment to the follow-up phase, from 60.1% to 49% (p < 0.0001), a finding that was particularly significant in nonremitters. Limitations of this study include the reliance on self-report of functioning and the lack of information on patients who dropped out.
conclusionThis study points to the importance of functional outcomes of MDD treatment as well as the need to develop personalized interventions to improve functioning in MDD.
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