Evidence map›Paper›PMID 27347360›Full record

ArticleMedChemComm2016

Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitors.

Reji N Nair, Jitendra K Mishra, Fangzheng Li, Mariola Tortosa, Chunying Yang, Joanne R Doherty, Michael Cameron, John L Cleveland, William R Roush, Thomas D Bannister

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedChemComm, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Reji N NairDepartment of Chemistry, The Scripps Research Institute, 110 Scripps Way, Jupiter, FL 33458, USA.
Jitendra K MishraDepartment of Chemistry, The Scripps Research Institute, 110 Scripps Way, Jupiter, FL 33458, USA.
Fangzheng LiDepartment of Chemistry, The Scripps Research Institute, 110 Scripps Way, Jupiter, FL 33458, USA.
Mariola TortosaDepartment of Chemistry, The Scripps Research Institute, 110 Scripps Way, Jupiter, FL 33458, USA.
Chunying YangDepartment of Tumor Biology, Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Joanne R DohertyDepartment of Cancer Biology, The Scripps Research Institute, 110 Scripps Way, Jupiter, FL 33458, USA.
Michael CameronDepartment of Molecular Therapeutics, The Scripps Research Institute, 110 Scripps Way, Jupiter, FL 33458, USA.
John L ClevelandDepartment of Tumor Biology, Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
William R RoushDepartment of Chemistry, The Scripps Research Institute, 110 Scripps Way, Jupiter, FL 33458, USA.
Thomas D BannisterDepartment of Chemistry, The Scripps Research Institute, 110 Scripps Way, Jupiter, FL 33458, USA.
Scripps Research Institute · USJupiter Medical Center · USMoffitt Cancer Center · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
UHTS Implementation(Florida)U54MH084512 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI ROSEN, HUGH · 2008 to 2013
$89.2M
Targeting Slc16a/Mct Lactate Transporters in Cancer TherapeuticsR01CA154739 · NCI · SCRIPPS FLORIDA · PI CLEVELAND, JOHN L., ROUSH, WILLIAM R · 2012 to 2016
$3.5M
Discovery and development of nociceptin receptor ligands in alcohol dependenceR01AA017943 · NIAAA · SCRIPPS FLORIDA · PI BANNISTER, THOMAS D · 2009 to 2010
$970k
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA154739NIAAA NIH HHS R01 AA017943NIMH NIH HHS U54 MH084512
6 · The paper itself

Abstract

Glutamine and tyrosine-based amino acid conjugates of monocarboxylate transporter types 1 and 2 inhibitors (MCT1/2) were designed, synthesized and evaluated for their potency in blocking the proliferation of a human B lymphoma cell line that expresses the transporters Asct2, LAT1 and MCT1. Appropriate placement of an amino acid transporter recognition element was shown to augment anti-tumour efficacy vs. Raji cells. Amino acid conjugation also improves the pharmacodynamic properties of experimental MCT1/2 inhibitors.

Identifiers

PMID27347360
PMCPMC4917231
OpenAlexW2280093696

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.