Evidence map›Paper›PMID 27347341›Full record

ArticleAmerican journal of translational research2016

Epidemiology and transmission characteristics of human adenovirus type 7 caused acute respiratory disease outbreak in military trainees in East China.

Jun Cheng, Xiaoping Qi, Dawei Chen, Xujian Xu, Guozheng Wang, Yuzhu Dai, Dawei Cui, Qingyong Chen, Ping Fan, Liuda Ni and 7 more

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 44 citations in OpenAlex.

  1. Trial
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  4. Adenovirus type 7d outbreak associated with severe clinical presentation, Finland, February to June 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
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  7. Construction and application of adenoviral vectors.Molecular therapy. Nucleic acids · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Jun ChengDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou, China; Department of Clinical Laboratory Science, The 117th Hospital of PLAHangzhou,China.
Xiaoping QiDepartment of Respiratory Medicine, The 117th Hospital of PLA Hangzhou, China.
Dawei ChenDepartment of Respiratory Medicine, The 117th Hospital of PLA Hangzhou, China.
Xujian XuDepartment of Biotechnology, The University of Tokyo Tokyo, Japan.
Guozheng WangDepartment of Clinical Laboratory Science, The 117th Hospital of PLA Hangzhou,China.
Yuzhu DaiDepartment of Clinical Laboratory Science, The 117th Hospital of PLA Hangzhou,China.
Dawei CuiState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou, China.
Qingyong ChenDepartment of Respiratory Medicine, The 117th Hospital of PLA Hangzhou, China.
Ping FanDepartment of Infectious Diseases, The 113rd Hospital of PLA Ningbo, China.
Liuda NiDepartment of Infectious Diseases, The 85th Hospital of PLA Shanghai, China.
Miao LiuDepartment of Radio Diagnosis and Imaging, The 117th Hospital of PLA Hangzhou, China.
Feiyan ZhuDepartment of Infectious Diseases, The 117th Hospital of PLA Hangzhou, China.
Mei YangDepartment of Epidemiology and Infection Control, The 117th Hospital of PLA Hangzhou, China.
Changjun WangInstitute of Military Medical Sciences of Nanjing Military Command Nanjing, China.
Yuexi LiCenter for Disease Control and Prevention of Nanjing Military Command Nanjing, China.
Changgui SunDepartment of Clinical Laboratory Science, The 117th Hospital of PLA Hangzhou,China.
Zhongyong WangDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, China.
117th Hospital of People's Liberation Army · CNNanjing General Hospital of Nanjing Military Command · CNWenzhou Medical University · CN82th Hospital of Pla · CNFirst Affiliated Hospital Zhejiang University · CNNingbo No. 2 Hospital · CNThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman adenovirus type 7 (HAdV7) is globally attracting great concern as its high morbidity and severity in respiratory diseases, especially in Asia.

objectiveTo investigate the clinical and epidemiologic characteristics of HAdV7 infection outbreak in East China.

methodsThe clinical samples were collected from the patients of an ARD outbreak in East Chinafor the detection of causative pathogens by multiplex PCR. The molecular type of human adenovirus isolates were identified by sequencing and homologous comparison based on their hexon genes. The spatiotemporal dynamics of global HAdV7 was investigated using the phylogenetic and phylogeographic analyses. Total 67 referenced HAdV7 hexon sequences (>800 bp) from GenBank were selected for constructing the maximum likelihood tree by MEGA 5.1.0, grouped according to the tree topology for the further migration analysis by PAUP* 4.0 and MigraPhyla 1.0 b to understand the transmission patterns of HAdV7 in global epidemics.

resultsThe results showed HAdV7 as the causative pathogen in this outbreak, and the outbreak strains had the hexon sequences highly identical with the isolates in Shaanxi (2012). The origin of HAdV7 was inferred as California, meanwhile a total of 21 migration routes were acquired. HAdV7 in this outbreak was statistically proven dispersed from Shaanxi province (2012).

conclusionsThe analyses of epidemiology and transmission pattern of HAdV7 would not only enrich the molecular biological basic database but also provide theoretical basis for HAdV7 prevention and control strategy.

Indexed as

clinical characteristicsepidemiologyHuman adenovirus type 7phylogenyphylogeography

Identifiers

PMID27347341
PMCPMC4891446
OpenAlexW2471614757

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.