Evidence map›Paper›PMID 27347336›Full record

ArticleAmerican journal of translational research2016

The hematologic effects of low intensity 650 nm laser irradiation on hypercholesterolemia rabbits.

Hong Wang, Juan Deng, Wenjun Tu, Lin Zhang, Hongli Chen, Xiaoguang Wu, Yingxin Li, Hong Sha

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Effect of 405 nm low intensity irradiation on the absorption spectrum of in-vitro hyperlipidemia blood.Technology and health care : official journal of the European Society for Engineering and Medicine · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hong WangInstitute of Biomedical Engineering, Academy of Medical Science and Peking Union Medical College Tianjin 300192, P. R. China.
Juan DengInstitute of Biomedical Engineering, Academy of Medical Science and Peking Union Medical College Tianjin 300192, P. R. China.
Wenjun TuInstitute of Radiation Medicine, Academy of Medical Science and Peking Union Medical College Tianjin 300192, P. R. China.
Lin ZhangDental Hospital of Tianjin Medical University Tianjin 300070, P. R. China.
Hongli ChenInstitute of Biomedical Engineering, Academy of Medical Science and Peking Union Medical College Tianjin 300192, P. R. China.
Xiaoguang WuInstitute of Biomedical Engineering, Academy of Medical Science and Peking Union Medical College Tianjin 300192, P. R. China.
Yingxin LiInstitute of Biomedical Engineering, Academy of Medical Science and Peking Union Medical College Tianjin 300192, P. R. China.
Hong ShaInstitute of Biomedical Engineering, Academy of Medical Science and Peking Union Medical College Tianjin 300192, P. R. China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNTianjin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo test the hematologic effects of low intensity 650 nm laser irradiation on hypercholesterolemia rabbits.

methodsTen male big-eared rabbits were selected from hypercholesterolemia animal model-making and divided into model group and laser treatment groups. Five normal rabbits were selected as control group. Auricle root irradiation of 650 nm laser 100 mW in 30 min were applied on treatment group twice a day, treatment of 6 days in one week, 20 weeks course of treatment. Changes in blood lipid, microcirculation, rheological properties, and aggregation morphology of erythrocytes were observed every two weeks. Histopathological examination were performed in the end of experiments.

resultsAfter 20 weeks' treatment, triglyceride (TG), cholesterol (CHO), high density lipoprotein (HDL) and low density lipoprotein (LDL) of serum in hypercholesterolemia groups showed less changes in the first 4 weeks, butdifferent decreasing trends were shownin the next 16 weeks' therapy. Erythrocytes aggregation of model groups showed rouleau state, while red blood cells in control group showed fine homodisperse, erythrocytes in treatment group performed better dispersion than model groups. Erythrocyte deformation index (DI) and blood flow value showed a statistic improvement in treatment group than control and model group (P<0.01). Value of DI in treatment group decreased after 18 weeks than values before therapy (P<0.01). Varying degrees of Aorta plaque formation was observed for individual difference in model and treatment groups, while no plaque was found in control group.

conclusionsLow energy laser improve microcirculation, rheological properties and blood lipid that might be related with erythrocytes aggregation and deformability.

Indexed as

blood microcirculationerythrocyteshyperlipidemiaLow intensity laser

Identifiers

PMID27347336
PMCPMC4891441
OpenAlexW2490147527

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.