Evidence map›Paper›PMID 27347239›Full record

ArticleThe open orthopaedics journal2016

Combined Cubital and Carpal Tunnel Release Results in Symptom Resolution Outside of the Median or Ulnar Nerve Distributions.

Peter C Chimenti, Allison W McIntyre, Sean M Childs, Warren C Hammert, John C Elfar

2 registry-linked trialsOpen access · hybridAbstract read
In one paragraph

Article in The open orthopaedics journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04026568 phase2 / phase3terminatednot on this mapstarted 2021, after this paper: background citation

A Single Dose Pharmaco-Diagnostic for Peripheral Nerve Continuity After Trauma

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2021 to 2022Enrolled1ConditionsNerve InjuryArms4-Aminopyridine, Placebo oral tablet
NCT06003166 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Pharmaco-Diagnostic Crossover Trial for Peripheral Nerve Continuity After Trauma

TypeinterventionalSponsorUniversity of ArizonaRan2025 to 2028Enrolled68ConditionsPeripheral Nerve Injury, Crush InjuryArms4-Aminopyridine, Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Peter C ChimentiUniversity of Rochester Medical Center, Rochester, New York, United States.
Allison W McIntyreUniversity of Rochester Medical Center, Rochester, New York, United States.
Sean M ChildsUniversity of Rochester Medical Center, Rochester, New York, United States.
Warren C HammertUniversity of Rochester Medical Center, Rochester, New York, United States.
John C ElfarUniversity of Rochester Medical Center, Rochester, New York, United States.
University of Rochester Medical Center · US

Funding

Erythropoietin for NeuroregenerationK08AR060164 · NIAMS · UNIVERSITY OF ROCHESTER · PI ELFAR, JOHN · 2013 to 2017
$578k
NIAMS NIH HHS K08 AR060164
6 · The paper itself

Abstract

backgroundResolution of symptoms including pain, numbness, and tingling outside of the median nerve distribution has been shown to occur following carpal tunnel release. We hypothesized that a similar effect would be found after combined release of the ulnar nerve at the elbow with simultaneous release of the median nerve at the carpal tunnel.

methods20 patients with combined cubital and carpal tunnel syndrome were prospectively enrolled. The upper extremity was divided into six zones and the location of pain, numbness, tingling, or strange sensations was recorded pre-operatively. Two-point discrimination, Semmes-Weinstein monofilament testing, and validated questionnaires were collected pre-operatively and at six-week follow-up.

resultsProbability of resolution was greater in the median nerve distribution than the ulnar nerve for numbness (71% vs. 43%), tingling (86% vs. 75%). Seventy percent of the cohort reported at least one extra-anatomic symptom pre-operatively, and greater than 80% of these resolved at early follow-up. There was a decrease in pain as measured by validated questionnaires.

conclusionThis study documents resolution of symptoms in both extra-ulnar and extra-median distributions after combined cubital and carpal tunnel release. Pre-operative patient counseling may therefore include the likelihood of symptomatic improvement in a non-expected nerve distribution after this procedure, assuming no other concomitant pathology which may cause persistent symptoms. Future studies could be directed at correlating pre-operative disease severity with probability of symptom resolution using a larger population.

Indexed as

Carpal Tunnel SyndromeCubital Tunnel SyndromeExtra-MedianExtra-UlnarMedian NerveUlnar NerveUlnar Neuropathy

Identifiers

PMID27347239
PMCPMC4897207
OpenAlexW2397699503

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.