ArticleThe open biomedical engineering journal2016
Modeling of Drug Delivery by A Pump Driven Micro-Needle Array System.
Article in The open biomedical engineering journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Mathematical Modelling, Simulation and Optimisation of Microneedles for Transdermal Drug Delivery: Trends and Progress.Pharmaceutics · 2020Review
- Skin drug permeability and safety through a vibrating solid micro-needle system.Drug delivery and translational research · 2018Article
- Fluid absorption by skin tissue during intradermal injections through hollow microneedles.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicro-needles were proposed as one of the alternatives to deliver drugs painlessly passing through stratum corneum in recent years. In this work, a mathematical model is presented to characterize the in fusion flow of a hollow micro-needle array driven by a micro-pump.
methodsBy assuming the injection of each micro-needle undergoes a spherical expansion and diffusion, the model is able to calculate the time-varying expansion radius, and the diffusion boundary, provided that the material properties and the micro-needle system parameters are known. RESULTS AND
conclusionThe calculation results show that the expansion caused by the infusion of micro-needles stops and the flow rate drops to zero in a short time. However, the diffusion boundary is much bigger than the expansion and the infusion continues if the surrounding material is absorptive. The experimental results of jet infusion through a single needle in silicon rubber and polyacrylamide gel agree with the calculation results qualitatively.
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Registered trials
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