Evidence map›Paper›PMID 27347139›Full record

ArticleOncology letters2016

Promoter hypermethylation and downregulation of the FAS gene may be involved in colorectal carcinogenesis.

Mehdi Manoochehri, Nasim Borhani, Ashraf Karbasi, Ameneh Koochaki, Bahram Kazemi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Mehdi ManoochehriBiotechnology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 19857-17453, Iran; School of Medicine, Shahroud University of Medical Sciences, Shahroud 36247-73955, Iran.
Nasim BorhaniSchool of Medicine, Shahroud University of Medical Sciences, Shahroud 36247-73955, Iran.
Ashraf KarbasiGastroenterology and Hepatology Department, Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran 14359-15371, Iran.
Ameneh KoochakiCell and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran 19857-17453, Iran.
Bahram KazemiBiotechnology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 19857-17453, Iran; Cell and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran 19857-17453, Iran.
Shahid Beheshti University of Medical Sciences · IRBaqiyatallah University of Medical Sciences · IRShahroud University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aberrant DNA methylation has been investigated in carcinogenesis and as biomarker for the early detection of colorectal cancer (CRC). The present study aimed to define the methylation status in the regulatory elements of two proapoptotic genes, Fas cell surface death receptor (FAS) and BCL2-associated X protein (BAX). DNA methylation analysis was performed in tumor and adjacent normal tissue using

Indexed as

apoptosiscolorectal cancerFas cell surface death receptorgene expressionmethylation

Identifiers

PMID27347139
PMCPMC4906593
OpenAlexW2401161026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.