Evidence map›Paper›PMID 27347135›Full record

ArticleOncology letters2016

Effect of therapy-related acute myeloid leukemia on the outcome of patients with acute myeloid leukemia.

Ana Espírito ESPíRITO Santo, Sérgio Chacim, Isabel Ferreira, Luís Leite, Claudia Moreira, Dulcineia Pereira, Margarida Dantas Dantas Brito, Marta Nunes, Nelson Domingues, Isabel Oliveira and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Ana Espírito ESPíRITO SantoDepartment of Onco-Hematology, Portuguese Institute of Oncology of Porto, Porto, Portugal; Faculty of Medicine, University of Porto, Porto, Portugal.
Sérgio ChacimDepartment of Onco-Hematology, Portuguese Institute of Oncology of Porto, Porto, Portugal.
Isabel FerreiraDepartment of Onco-Hematology, Portuguese Institute of Oncology of Porto, Porto, Portugal.
Luís LeiteDepartment of Onco-Hematology, Portuguese Institute of Oncology of Porto, Porto, Portugal.
Claudia MoreiraDepartment of Onco-Hematology, Portuguese Institute of Oncology of Porto, Porto, Portugal.
Dulcineia PereiraDepartment of Onco-Hematology, Portuguese Institute of Oncology of Porto, Porto, Portugal.
Margarida Dantas Dantas BritoDepartment of Onco-Hematology, Portuguese Institute of Oncology of Porto, Porto, Portugal.
Marta NunesDepartment of Onco-Hematology, Portuguese Institute of Oncology of Porto, Porto, Portugal.
Nelson DominguesDepartment of Onco-Hematology, Portuguese Institute of Oncology of Porto, Porto, Portugal.
Isabel OliveiraDepartment of Onco-Hematology, Portuguese Institute of Oncology of Porto, Porto, Portugal.
Ilídia MoreiraDepartment of Onco-Hematology, Portuguese Institute of Oncology of Porto, Porto, Portugal.
Angelo MartinsDepartment of Onco-Hematology, Portuguese Institute of Oncology of Porto, Porto, Portugal.
Luísa ViterboDepartment of Onco-Hematology, Portuguese Institute of Oncology of Porto, Porto, Portugal.
José Mário MarizDepartment of Onco-Hematology, Portuguese Institute of Oncology of Porto, Porto, Portugal.
Rui MedeirosMolecular Oncology and Viral Pathology Group Investigation Centre, Portuguese Institute of Oncology of Porto, Porto, Portugal; Abel Salazar Institute of Biomedical Sciences, University of Porot, Porto, Portugal; Department of Oncology, Portuguese Institute of Oncology, Porto, Portugal; Biomedical Research Centre, Faculty of Health Sciences of Fernando Pessoa University, Porto, Portugal; Department of Research, Portuguese League Against Cancer (Regional North Core), Porto, Portugal.
Instituto Português de Oncologia Francisco Gentil · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapy-related acute myeloid leukemia (t-AML) is a rare and almost always fatal late side effect of antineoplastic treatment involving chemotherapy, radiotherapy or the two combined. The present retrospective study intended to characterize t-AML patients that were diagnosed and treated in a single referral to an oncological institution in North Portugal. Over the past 10 years, 231 cases of AML were diagnosed and treated at the Portuguese Institute of Oncology of Porto, of which 38 t-AML cases were identified. Data regarding the patient demographics, primary diagnosis and treatment, age at onset of therapy-related myeloid neoplasm, latency time of the neoplasm, cytogenetic characteristics, AML therapy and outcome were collected from medical records. A previous diagnosis with solid tumors was present in 28 patients, and 10 patients possessed a history of hematological conditions, all a lymphoproliferative disorder. Breast cancer was the most frequent solid tumor identified (39.5% of all solid tumors diagnosed). The mean latency time was 3 years. In the present study, t-AML patients were older (P<0.001) and more frequently carried cytogenetic abnormalities (P=0.009) compared with

Indexed as

acute myeloid leukemiaagecytogeneticstherapy-related acute myeloid leukemia

Identifiers

PMID27347135
PMCPMC4907087
OpenAlexW2403395456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.