Evidence map›Paper›PMID 27347089›Full record

ArticleExperimental and therapeutic medicine2016

Leukotriene D4 nasal provocation test: Rationale, methodology and diagnostic value.

Zheng Zhu, Yanqing Xie, Weijie Guan, Y I Gao, Shu Xia, Jianxin Liang, Jinping Zheng

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Effects of leukotriene DJournal of thoracic disease · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Zheng ZhuState Key Laboratory of Respiratory Disease, China Clinical Research Center of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
Yanqing XieState Key Laboratory of Respiratory Disease, China Clinical Research Center of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
Weijie GuanState Key Laboratory of Respiratory Disease, China Clinical Research Center of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
Y I GaoState Key Laboratory of Respiratory Disease, China Clinical Research Center of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
Shu XiaState Key Laboratory of Respiratory Disease, China Clinical Research Center of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
Jianxin LiangDepartment of Otorhinolaryngology, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
Jinping ZhengState Key Laboratory of Respiratory Disease, China Clinical Research Center of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
Guangzhou Medical University · CNFirst Affiliated Hospital of Guangzhou Medical University · CNState Key Laboratory of Respiratory Disease · CN

Funding

Therapeutic Strategy for LAM (Lymphangioleiomyomatosis)UH3TR000961 · NCATS · BAYLOR COLLEGE OF MEDICINE · PI EISSA, N. TONY · 2014 to 2016
$3.0M
Therapeutic Strategy for LAM (Lymphangioleiomyomatosis)UH2TR000961 · NCATS · BAYLOR COLLEGE OF MEDICINE · PI EISSA, N. TONY · 2013 to 2013
$1.3M
NCATS NIH HHS UH2 TR000961NCATS NIH HHS UH3 TR000961
6 · The paper itself

Abstract

Cysteinyl leukotrienes (LT) play a vital role in the pathogenesis of allergic rhinitis (AR), but few studies have investigated the nasal mucosal physiological response to LTs in AR patients. The aim of the present study was to establish the methodology and investigate the diagnostic value and safety of a leukotriene D4 (LTD4) nasal provocation test. LTD4 nasal provocation tests were performed in 26 AR patients and 16 normal control subjects. Nasal airway responsiveness was assessed by calculating the concentration of LTD4 required to cause a 60% increase in nasal airway resistance (PC

Indexed as

allergic rhinitishyperresponsivenessleukotriene D4methodologyprovocation test

Identifiers

PMID27347089
PMCPMC4906572
OpenAlexW2350371283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.