ArticleJournal of biological engineering2016
Optimization of the fermentation process of Cordyceps sobolifera Se-CEPS and its anti-tumor activity in vivo.
Article in Journal of biological engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 34 citations in OpenAlex.
- Selenized Polysaccharides From Acanthopanax leucorrhizus: Synthesis, Characterization, and Cytotoxicity.Chemistry & biodiversity · 2026Article
- Optimization of triterpenoids biosynthesis in Athelia termitophila as a source of natural products.AMB Express · 2025Article
- Review
- Exploiting the roles of nitrogen sources for HEA increment inFrontiers in microbiology · 2024Article
- Enhanced production of cordycepic acid from Cordyceps cicadae isolated from a wild environment.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Structural Characterization of Mannoglucan Isolated fromACS omega · 2022Article
- Systematic expression analysis of the CELSR family reveals the importance of CELSR3 in human lung adenocarcinoma.Journal of cellular and molecular medicine · 2021Article
- Intraocular pressure-lowering effect ofInternational journal of medical sciences · 2021Article
- Evaluation of the mechanism of cordyceps polysaccharide action on rat acute liver failure.Archives of medical science : AMS · 2020Article
- Current nomenclatural changes inMycology · 2017Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCordyceps sobolifera (C. sobolifera) isolated from cicadae was used as the starting fungus to produce selenium-enriched C. sobolifera extracellular polysaccharide (Se-CEPS). An orthogonal experimental design based on a single-factor experiment was used to optimize the C. sobolifera fermentation conditions, including the potato juice, peptone, and KH2PO4 concentrations. Ultraviolet (UV) and infrared (IR) analyses of CEPS and Se-CEPS were conducted, as well as an in vivo anti-tumor analysis.
resultsUnder optimal conditions (i.e., 40 potato juice, 0.4 KH2PO4, and 0.5 % peptone), the fermentation yield of Se-CEPS was 5.64 g/L. UV and IR spectra showed that Se-CEPS contained a characteristic absorption peak of a selenite Se = O double bond, demonstrating the successful preparation of Se-CEPS. Activity tests showed that Se-CEPS improved the immune organ index, serum cytokine content, and CD8(+) and CD4(+) T lymphocyte ratio in colon cancer CT26 tumor-bearing mice, thereby inhibiting tumor growth. When combined with 5-FU, Se-CEPS reduced the toxicity and enhanced the function of 5-FU.
conclusionThe result of these experiments indicated that orthogonal experimental design is a promising method for the optimization of Se-CEPS production, and the Se-CEPS from C. sobolifera can improve the anti-tumor capacity of mice.
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