ArticleTechniques in orthopaedics (Rockville, Md.)2016
Current Status of Tissue-Engineered Scaffolds for Rotator Cuff Repair.
Article in Techniques in orthopaedics (Rockville, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Engineering a biomimetic multiphasic suture anchor system for enhanced rotator cuff enthesis regeneration.Science advances · 2026Article
- Biologic augmentation in rotator cuff repair: current evidence and future directions.JSES reviews, reports, and techniques · 2026Review
- Surgical Options for Massive Rotator Cuff Tears with Preserved Full Range of Motion in Middle-Aged Patients.Clinics in orthopedic surgery · 2026Review
- Mesoporous bioactive glass hybrid nanoparticles accelerate tendon-bone healing via synergistic angiogenesis and immunomodulation.Materials today. Bio · 2026Article
- Turmeric-derived extracellular vesicles loaded microneedle system attenuates rotator cuff degeneration by orchestrating energetic metabolism.Materials today. Bio · 2025Article
- Engineering a Biomimetic Multiphasic Suture Anchor System for Enhanced Rotator Cuff Enthesis Regeneration.bioRxiv : the preprint server for biology · 2025Article
- Biological Augmentation Using Electrospun Constructs with Dual Growth Factor Release for Rotator Cuff Repair.ACS applied bio materials · 2025Article
- Challenges in tendon-bone healing: emphasizing inflammatory modulation mechanisms and treatment.Frontiers in endocrinology · 2024Review
- Tissue-engineered tendon nano-constructs for repair of chronic rotator cuff tears in large animal models.Bioengineering & translational medicine · 2023Article
- Bioactive extracellular matrix fragments in tendon repair.Cell and tissue research · 2022Review
- Exosomes derived from magnetically actuated bone mesenchymal stem cells promote tendon-bone healing through the miR-21-5p/SMAD7 pathway.Materials today. Bio · 2022Article
- Mesenchymal Stem Cell Sheets for Engineering of the Tendon-Bone Interface.Tissue engineering. Part A · 2022Article
- A bio-inductive collagen scaffold that supports human primary tendon-derived cell growth for rotator cuff repair.Journal of orthopaedic translation · 2021Article
- The Role of Collagen-Based Biomaterials in Chronic Wound Healing and Sports Medicine Applications.Bioengineering (Basel, Switzerland) · 2021Review
- Synergistic enhancement of tendon-to-bone healing via anti-inflammatory and pro-differentiation effects caused by sustained release of MgTheranostics · 2021Article
- Nanofiber Scaffolds by Electrospinning for Rotator Cuff Tissue Engineering.Chonnam medical journal · 2021Review
- Bone marrow mesenchymal stem cell-derived exosomes promote rotator cuff tendon-bone healing by promoting angiogenesis and regulating M1 macrophages in rats.Stem cell research & therapy · 2020Article
- Tendon-Inspired Nanotopographic Scaffold for Tissue Regeneration in Rotator Cuff Injuries.ACS omega · 2020Article
- Article
- Growth factor delivery strategies for rotator cuff repair and regeneration.International journal of pharmaceutics · 2018Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Rotator cuff tears continue to be at significant risk for re-tear or for failure to heal after surgical repair despite the use of a variety of surgical techniques and augmentation devices. Therefore, there is a need for functionalized scaffold strategies to provide sustained mechanical augmentation during the critical first 12-weeks following repair, and to enhance the healing potential of the repaired tendon and tendon-bone interface. Tissue engineered approaches that combine the use of scaffolds, cells, and bioactive molecules towards promising new solutions for rotator cuff repair are reviewed. The ideal scaffold should have adequate initial mechanical properties, be slowly degrading or non-degradable, have non-toxic degradation products, enhance cell growth, infiltration and differentiation, promote regeneration of the tendon-bone interface, be biocompatible and have excellent suture retention and handling properties. Scaffolds that closely match the inhomogeneity and non-linearity of the native rotator cuff may significantly advance the field. While substantial pre-clinical work remains to be done, continued progress in overcoming current tissue engineering challenges should allow for successful clinical translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.