Evidence map›Paper›PMID 27346899›Full record

ArticleAngewandte Chemie (Weinheim an der Bergstrasse, Germany)2016

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

André A Neves, Yéléna A Wainman, Alan Wright, Mikko I Kettunen, Tiago B Rodrigues, Sarah McGuire, De-En Hu, Flaviu Bulat, Simonetta Geninatti Crich, Henning Stöckmann and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

André A NevesCancer Research UK Cambridge Institute Li Ka Shing Centre Cambridge CB2 0RE UK.ORCID 0000-0003-2740-5166
Yéléna A WainmanCancer Research UK Cambridge Institute Li Ka Shing Centre Cambridge CB2 0RE UK; Department of Chemistry University of Cambridge Cambridge CB2 1EW UK.
Alan WrightCancer Research UK Cambridge Institute Li Ka Shing Centre Cambridge CB2 0RE UK.
Mikko I KettunenCancer Research UK Cambridge InstituteLi Ka Shing Centre Cambridge CB2 0RE UK; A. I. Virtanen Institute for Molecular Sciences University of Eastern Finland Neulaniementie 2 70211 Kuopio Finland.
Tiago B RodriguesCancer Research UK Cambridge Institute Li Ka Shing Centre Cambridge CB2 0RE UK.
Sarah McGuireCancer Research UK Cambridge Institute Li Ka Shing Centre Cambridge CB2 0RE UK.
De-En HuCancer Research UK Cambridge Institute Li Ka Shing Centre Cambridge CB2 0RE UK.
Flaviu BulatDepartment of Chemistry University of Cambridge Cambridge CB2 1EW UK.
Simonetta Geninatti CrichDepartment of Molecular Biotechnology and Health Science Molecular Imaging Center Via Nizza 52 10126 Turin Italy.
Henning StöckmannDepartment of Chemistry University of Cambridge Cambridge CB2 1EW UK.
Finian J LeeperDepartment of Chemistry University of Cambridge Cambridge CB2 1EW UK.ORCID 0000-0003-3408-5199
Kevin M BrindleCancer Research UK Cambridge Institute Li Ka Shing Centre Cambridge CB2 0RE UK.ORCID 0000-0003-3883-6287

Funding

Cancer Research UK 16465Cancer Research UK 17242
6 · The paper itself

Abstract

Glycosylation is a ubiquitous post-translational modification, present in over 50 % of the proteins in the human genome,1 with important roles in cell-cell communication and migration. Interest in glycome profiling has increased with the realization that glycans can be used as biomarkers of many diseases,2 including cancer.3 We report here the first tomographic imaging of glycosylated tissues in live mice by using metabolic labeling and a gadolinium-based bioorthogonal MRI probe. Significant

Indexed as

Bioorthogonale ChemieGadoliniumGlykaneKrebsMagnetresonanztomographie

Identifiers

PMID27346899
PMCPMC4848764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.