ArticleAngewandte Chemie (Weinheim an der Bergstrasse, Germany)2015
Reversible Control of Nanoparticle Functionalization and Physicochemical Properties by Dynamic Covalent Exchange.
Article in Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Rapidly Adaptive All-covalent Nanoparticle Surface Engineering.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Dynamic Covalent Nanoparticle Building Blocks.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Article
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Authors and funding
2 authors.
Funding
Abstract
Existing methods for the covalent functionalization of nanoparticles rely on kinetically controlled reactions, and largely lack the sophistication of the preeminent oligonucleotide-based noncovalent strategies. Here we report the application of dynamic covalent chemistry for the reversible modification of nanoparticle (NP) surface functionality, combining the benefits of non-biomolecular covalent chemistry with the favorable features of equilibrium processes. A homogeneous monolayer of nanoparticle-bound hydrazones can undergo quantitative dynamic covalent exchange. The pseudomolecular nature of the NP system allows for the in situ characterization of surface-bound species, and real-time tracking of the exchange reactions. Furthermore, dynamic covalent exchange offers a simple approach for reversibly switching-and subtly tuning-NP properties such as solvophilicity.
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