ArticleScientific reports2016
Mice that lack the C-terminal region of Reelin exhibit behavioral abnormalities related to neuropsychiatric disorders.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Reelin Alterations, Behavioral Phenotypes, and Brain Anomalies in Schizophrenia: A Systematic Review of Insights From Rodent Models.Frontiers in neuroanatomy · 2022Pooled it
- Repeated behavioral testing and the use of summary measures reveal trait anxiety in preclinical rodent models.Translational psychiatry · 2025Article
- Reelin marks cocaine-activated striatal neurons, promotes neuronal excitability, and regulates cocaine reward.Science advances · 2025Article
- Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent.Frontiers in molecular neuroscience · 2025Review
- Article
- Reelin Signaling in Neurodevelopmental Disorders and Neurodegenerative Diseases.Brain sciences · 2023Review
- HeterozygouseNeuro · 2023Article
- Altered motor learning and coordination in mouse models of autism spectrum disorder.Frontiers in cellular neuroscience · 2023Review
- The Pathophysiological Link Between Reelin and Autism: Overview and New Insights.Frontiers in genetics · 2022Review
- Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: BeyondBrain sciences · 2021Review
- Article
- Reelin-Nrp1 Interaction Regulates Neocortical Dendrite Development in a Context-Specific Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Reelin Mediates Hippocampal Cajal-Retzius Cell Positioning and Infrapyramidal Blade Morphogenesis.Journal of developmental biology · 2020Article
- Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders.Pharmacology & therapeutics · 2020Review
- Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia.Psychiatry and clinical neurosciences · 2020Article
- Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice.Scientific reports · 2020Article
- Depression-/Anxiety-Like Behavior Alterations in Adult Slit2 Transgenic Mice.Frontiers in behavioral neuroscience · 2020Article
- Reelin Supplementation Into the Hippocampus Rescues Abnormal Behavior in a Mouse Model of Neurodevelopmental Disorders.Frontiers in cellular neuroscience · 2020Article
- Open source code for behavior analysis in rodents.Neuropsychopharmacology reports · 2019Article
- Reelin Signaling Controls the Preference for Social Novelty in Zebrafish.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The secreted glycoprotein Reelin is believed to play critical roles in the pathogenesis of several neuropsychiatric disorders. The highly basic C-terminal region (CTR) of Reelin is necessary for efficient activation of its downstream signaling, and the brain structure of knock-in mice that lack the CTR (ΔC-KI mice) is impaired. Here, we performed a comprehensive behavioral test battery on ΔC-KI mice, in order to evaluate the effects of partial loss-of-function of Reelin on brain functions. The ΔC-KI mice were hyperactive and exhibited reduced anxiety-like and social behaviors. The working memory in ΔC-KI mice was impaired in a T-maze test. There was little difference in spatial reference memory, depression-like behavior, prepulse inhibition, or fear memory between ΔC-KI and wild-type mice. These results suggest that CTR-dependent Reelin functions are required for some specific normal brain functions and that ΔC-KI mice recapitulate some aspects of neuropsychiatric disorders, such as schizophrenia, bipolar disorder, and autism spectrum disorder.
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Registered trials
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