Evidence map›Paper›PMID 27346678›Full record

ArticleNanotechnology2016

A 3D printed nano bone matrix for characterization of breast cancer cell and osteoblast interactions.

Wei Zhu, Nathan J Castro, Haitao Cui, Xuan Zhou, Benchaa Boualam, Robert McGrane, Robert I Glazer, Lijie Grace Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 71 citations in OpenAlex.

  1. Review
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  4. Cancer metastasisFrontiers in bioengineering and biotechnology · 2026
    Review
  5. 3D bioprinting innovations: a new frontier in breast cancer research.Medical oncology (Northwood, London, England) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Wei ZhuDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington DC 20052, USA.
Nathan J CastroDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington DC 20052, USA.
Haitao CuiDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington DC 20052, USA.
Xuan ZhouDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington DC 20052, USA.
Benchaa BoualamCollege of Computer, Mathematical and Natural Sciences, University of Maryland-College Park, College Park, MD 20742, USA.
Robert McGraneDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington DC 20052, USA.
Robert I GlazerDepartment of Oncology, and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20007, USA.
Lijie Grace ZhangDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington DC 20052, USA.
George Washington University · USGeorgetown University Medical Center · USUniversity of Maryland, College Park · US

Funding

A Novel 3D Bioprinted Smart Vascularized Nano TissueDP2EB020549 · NIBIB · GEORGE WASHINGTON UNIVERSITY · PI ZHANG, LIJIE GRACE · 2014 to 2014
$2.3M
NIBIB NIH HHS DP2 EB020549
6 · The paper itself

Abstract

Bone metastasis is one of the most prevalent complications of late-stage breast cancer, in which the native bone matrix components, including osteoblasts, are intimately involved in tumor progression. The development of a successful in vitro model would greatly facilitate understanding the underlying mechanism of breast cancer bone invasion as well as provide a tool for effective discovery of novel therapeutic strategies. In the current study, we fabricated a series of in vitro bone matrices composed of a polyethylene glycol hydrogel and nanocrystalline hydroxyapatite of varying concentrations to mimic the native bone microenvironment for the investigation of breast cancer bone metastasis. A stereolithography-based three-dimensional (3D) printer was used to fabricate the bone matrices with precisely controlled architecture. The interaction between breast cancer cells and osteoblasts was investigated in the optimized bone matrix. Using a Transwell

Identifiers

PMID27346678
PMCPMC5192011
OpenAlexW2461545510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.