Evidence map›Paper›PMID 27346644›Full record

ReviewMolecular nutrition & food research2017

Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases.

Kyle T Dolan, Eugene B Chang

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Molecular nutrition & food research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04552405 (Preventive Anti-inflammatory Diet to Reduce Gastro-intestinal Inflammation in FAP Patients), which is not on this map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04552405 nacompletednot on this map

Preventive Anti-inflammatory Diet to Reduce Gastro-intestinal Inflammation in FAP Patients: a Prospective Pilot Study

TypeinterventionalSponsorFondazione IRCCS Istituto Nazionale dei Tumori, MilanoRan2017 to 2018Enrolled35ConditionsFamilial Adenomatous Polyposis (FAP)ArmsAnti-inflammatory Diet
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kyle T DolanSection of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, The University of Chicago.
Eugene B ChangSection of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, The University of Chicago.
University of Chicago · US

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
Research Training in Digestive Health, Diseases, and NutritionT32DK007074 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG · 1986 to 2026
$11.3M
Dietary fat effects on gut microbes, host immune state and experimental colitisR01DK097268 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 2012 to 2016
$2.2M
Diet induced obesity from gut microbial disruption of host metabolic networksR56DK102872 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B, JONES, DEAN PAUL · 2015 to 2015
$409k
NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK097268NIDDK NIH HHS R56 DK102872NIDDK NIH HHS T32 DK007074
6 · The paper itself

Abstract

The rising incidence of inflammatory bowel diseases in recent decades has notably paralleled changing lifestyle habits in Western nations, which are now making their way into more traditional societies. Diet plays a key role in IBD pathogenesis, and there is a growing appreciation that the interaction between diet and microbes in a susceptible person contributes significantly to the onset of disease. In this review, we examine what is known about dietary and microbial factors that promote IBD. We summarize recent findings regarding the effects of diet in IBD epidemiology from prospective population cohort studies, as well as new insights into IBD-associated dysbiosis. Microbial metabolism of dietary components can influence the epithelial barrier and the mucosal immune system, and understanding how these interactions generate or suppress inflammation will be a significant focus of IBD research. Our knowledge of dietary and microbial risk factors for IBD provides important considerations for developing therapeutic approaches through dietary modification or re-shaping the microbiota. We conclude by calling for increased sophistication in designing studies on the role of diet and microbes in IBD pathogenesis and disease resolution in order to accelerate progress in response to the growing challenge posed by these complex disorders.

Indexed as

DietGastrointestinal MicrobiomeGastroenteritisHumansInflammatory Bowel DiseasesIntestinal MucosaRisk FactorsDietIBDMicrobial metabolismMicrobiotaPathogenesis

Identifiers

PMID27346644
PMCPMC5331923
OpenAlexW2466878065

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.