Evidence map›Paper›PMID 27346614›Full record

ReviewAdvances in clinical chemistry

Circulating Tumor Cell Isolation and Analysis.

J Zhang, K Chen, Z H Fan

Open access · greenAbstract readReview
In one paragraph

Review in Advances in clinical chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
24.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 78 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Circulating Tumor Cells: Emerging Frontiers in Cancer Technology.Expert reviews in molecular medicine · 2026
    Review
  6. Review
  7. [Detection of circulating tumor cells in women with early breast cancer].Revista medica del Instituto Mexicano del Seguro Social · 2024
    Observational
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. The Protocol of Circulating Tumor Cell Detection.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  14. Review
  15. Article
  16. Application of Microfluidics in Detection of Circulating Tumor Cells.Frontiers in bioengineering and biotechnology · 2022
    Review
  17. Review
  18. Liquid biopsy in NSCLC: a new challenge in radiation therapy.Exploration of targeted anti-tumor therapy · 2021
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

J ZhangUniversity of Florida, Gainesville, FL, United States.
K ChenUniversity of Florida, Gainesville, FL, United States.
Z H FanUniversity of Florida, Gainesville, FL, United States. Electronic address: hfan@ufl.edu.
University of Florida · US

Funding

Mentored Quantitative Research Career Development AwardK25CA149080 · NCI · UNIVERSITY OF FLORIDA · PI FAN, Z. HUGH · 2011 to 2015
$897k
Microfluidics-enabled Immunoassay Array for Multianalyte DetectionR21GM103535 · NIGMS · UNIVERSITY OF FLORIDA · PI FAN, Z. HUGH · 2012 to 2013
$342k
NCI NIH HHS K25 CA149080NIGMS NIH HHS R21 GM103535
6 · The paper itself

Abstract

Isolation and analysis of cancer cells from body fluids have significant implications in diagnosis and therapeutic treatment of cancers. Circulating tumor cells (CTCs) are cancer cells circulating in the peripheral blood or spreading iatrogenically into blood vessels, which is an early step in the cascade of events leading to cancer metastasis. Therefore, CTCs can be used for diagnosing for therapeutic treatment, prognosing a given anticancer intervention, and estimating the risk of metastatic relapse. However, isolation of CTCs is a significant technological challenge due to their rarity and low recovery rate using traditional purification techniques. Recently microfluidic devices represent a promising platform for isolating cancer cells with high efficiency in processing complex cellular fluids, with simplicity, sensitivity, and throughput. This review summarizes recent methods of CTC isolation and analysis, as well as their applications in clinical studies.

Indexed as

AnimalsAntineoplastic AgentsCell SeparationHumansNeoplastic Cells, CirculatingAntineoplastic AgentsBiomarkersCancerCirculating tumor cellsDiagnosisMicrofluidics

Identifiers

PMID27346614
PMCPMC5123699
OpenAlexW2369470577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.