Evidence map›Paper›PMID 27346372›Full record

ArticleScientific reports2016

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls.

Jun Chen, Nicholas Chia, Krishna R Kalari, Janet Z Yao, Martina Novotna, M Mateo Paz Soldan, David H Luckey, Eric V Marietta, Patricio R Jeraldo, Xianfeng Chen and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 518 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
518citing papers in PubMed, 8 pooled it
46.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

518 citing papers in PubMed, 8 syntheses or guidelines pooled it, 963 citations in OpenAlex.

  1. Pooled it
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  6. Changes in Gut Microbiota and Multiple Sclerosis: A Systematic Review.International journal of environmental research and public health · 2023
    Pooled it
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  15. Significant changes in the fecal bacteriobiota richness and diversity in patients with relapsing-remitting multiple sclerosis compared to healthy individuals.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  16. Article
  17. Review
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458 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Jun ChenDivision of Biomedical Statistics and Informatics-Department of Health Sciences Research Mayo Clinic, 200 1st ST SW, Rochester, MN -55905, USA.
Nicholas ChiaDepartment of Surgical Research Mayo Clinic, 200 1st ST SW, Rochester, MN -55905, USA.
Krishna R KalariDivision of Biomedical Statistics and Informatics-Department of Health Sciences Research Mayo Clinic, 200 1st ST SW, Rochester, MN -55905, USA.
Janet Z YaoDepartment of Surgical Research Mayo Clinic, 200 1st ST SW, Rochester, MN -55905, USA.
Martina NovotnaMayo Clinic Center for Multiple Sclerosis and CNS Demyelinating Diseases, Department of Neurology, Mayo Clinic College of Medicine, 200 1st ST SW, Rochester, MN-55905, USA.
M Mateo Paz SoldanMayo Clinic Center for Multiple Sclerosis and CNS Demyelinating Diseases, Department of Neurology, Mayo Clinic College of Medicine, 200 1st ST SW, Rochester, MN-55905, USA.
David H LuckeyDepartment of Immunology Mayo Clinic, 200 1st ST SW, Rochester, MN -55905, USA.
Eric V MariettaDepartment of Gastroenterology, Mayo Clinic, Rochester, MN-55905, USA.
Patricio R JeraldoDepartment of Surgical Research Mayo Clinic, 200 1st ST SW, Rochester, MN -55905, USA.
Xianfeng ChenDivision of Biomedical Statistics and Informatics-Department of Health Sciences Research Mayo Clinic, 200 1st ST SW, Rochester, MN -55905, USA.
Brian G WeinshenkerMayo Clinic Center for Multiple Sclerosis and CNS Demyelinating Diseases, Department of Neurology, Mayo Clinic College of Medicine, 200 1st ST SW, Rochester, MN-55905, USA.
Moses RodriguezMayo Clinic Center for Multiple Sclerosis and CNS Demyelinating Diseases, Department of Neurology, Mayo Clinic College of Medicine, 200 1st ST SW, Rochester, MN-55905, USA.
Orhun H KantarciMayo Clinic Center for Multiple Sclerosis and CNS Demyelinating Diseases, Department of Neurology, Mayo Clinic College of Medicine, 200 1st ST SW, Rochester, MN-55905, USA.
Heidi NelsonDepartment of Surgical Research Mayo Clinic, 200 1st ST SW, Rochester, MN -55905, USA.
Joseph A MurrayDepartment of Immunology Mayo Clinic, 200 1st ST SW, Rochester, MN -55905, USA.
Ashutosh K MangalamDepartment of Immunology Mayo Clinic, 200 1st ST SW, Rochester, MN -55905, USA.
Mayo Clinic · USMayo Clinic in Florida · USMayo Clinic in Arizona · USUniversity of Iowa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of MS. Therefore, this study was designed to investigate whether gut microbiota are altered in MS by comparing the fecal microbiota in relapsing remitting MS (RRMS) (n = 31) patients to that of age- and gender-matched healthy controls (n = 36). Phylotype profiles of the gut microbial populations were generated using hypervariable tag sequencing of the V3-V5 region of the 16S ribosomal RNA gene. Detailed fecal microbiome analyses revealed that MS patients had distinct microbial community profile compared to healthy controls. We observed an increased abundance of Psuedomonas, Mycoplana, Haemophilus, Blautia, and Dorea genera in MS patients, whereas control group showed increased abundance of Parabacteroides, Adlercreutzia and Prevotella genera. Thus our study is consistent with the hypothesis that MS patients have gut microbial dysbiosis and further study is needed to better understand their role in the etiopathogenesis of MS.

Indexed as

AdultDysbiosisFemaleGastrointestinal MicrobiomeGastrointestinal TractHumansMaleMicrobiotaMultiple SclerosisRNA, Ribosomal, 16SRNA, Ribosomal, 16S

Identifiers

PMID27346372
PMCPMC4921909
OpenAlexW2461582275

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.