ArticleCell reports2016
5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4(+) T Cells.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 64 citations in OpenAlex.
- Tissue repair in the central nervous system: the epigenetic programming of regulatory T cells.Frontiers in immunology · 2026Review
- Cell identity and 5-hydroxymethylcytosine.Epigenetics & chromatin · 2025Review
- Exploring the Ascorbate Requirement of the 2-Oxoglutarate-Dependent Dioxygenases.Journal of medicinal chemistry · 2025Review
- TET proteins regulate Drosha expression and impact microRNAs in iNKT cells.bioRxiv : the preprint server for biology · 2024Article
- Decoding the role of DNA methylation in allergic diseases: from pathogenesis to therapy.Cell & bioscience · 2024Review
- Single-Molecule DNA Methylation Reveals Unique Epigenetic Identity Profiles of T Helper Cells.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Literary Identification of Differentially Hydroxymethylated DNA Regions for Type 2 Diabetes Mellitus: A Scoping Minireview.International journal of environmental research and public health · 2024Article
- Plasma cell-free DNA hydroxymethylation profiling reveals anti-PD-1 treatment response and resistance biology in non-small cell lung cancer.Journal for immunotherapy of cancer · 2024Article
- TET proteins regulateFrontiers in immunology · 2024Article
- Integrative multi-omics approaches to explore immune cell functions: Challenges and opportunities.iScience · 2023Review
- Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages.Clinical epigenetics · 2022Article
- TET2 Regulates 5-Hydroxymethylcytosine Signature and CD4Allergy, asthma & immunology research · 2022Article
- Micro but mighty-Micronutrients in the epigenetic regulation of adaptive immune responses.Immunological reviews · 2022Review
- Estimating DNA methylation potential energy landscapes from nanopore sequencing data.Scientific reports · 2021Article
- Deciphering the multifaceted roles of TET proteins in T-cell lineage specification and malignant transformation.Immunological reviews · 2021Review
- Active DNA demethylation-The epigenetic gatekeeper of development, immunity, and cancer.Advanced genetics (Hoboken, N.J.) · 2021Review
- Role of Methylation in Pro- and Anti-Cancer Immunity.Cancers · 2021Review
- TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition.Leukemia · 2021Article
- Review
- Thyroid Hormone Induces DNA Demethylation in Xenopus Tadpole Brain.Endocrinology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
Abstract
5-methylcytosine (5mC) is converted to 5-hydroxymethylcytosine (5hmC) by the TET family of enzymes as part of a recently discovered active DNA de-methylation pathway. 5hmC plays important roles in regulation of gene expression and differentiation and has been implicated in T cell malignancies and autoimmunity. Here, we report early and widespread 5mC/5hmC remodeling during human CD4(+) T cell differentiation ex vivo at genes and cell-specific enhancers with known T cell function. We observe similar DNA de-methylation in CD4(+) memory T cells in vivo, indicating that early remodeling events persist long term in differentiated cells. Underscoring their important function, 5hmC loci were highly enriched for genetic variants associated with T cell diseases and T-cell-specific chromosomal interactions. Extensive functional validation of 22 risk variants revealed potentially pathogenic mechanisms in diabetes and multiple sclerosis. Our results support 5hmC-mediated DNA de-methylation as a key component of CD4(+) T cell biology in humans, with important implications for gene regulation and lineage commitment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.