ArticleCell reports2016
Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Structural insights into kainate receptor desensitization.Nature communications · 2025Article
- Article
- Enhanced Membrane Incorporation of H289Y Mutant GluK1 Receptors from the Audiogenic Seizure-Prone GASH/Sal Model: Functional and Morphological Impacts onInternational journal of molecular sciences · 2023Article
- Activation of Extrasynaptic Kainate Receptors Drives Hilar Mossy Cell Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Neuronal surface antigen-specific immunostaining pattern on a rat brain immunohistochemistry in autoimmune encephalitis.Frontiers in immunology · 2022Article
- Structural and compositional diversity in the kainate receptor family.Cell reports · 2021Article
- Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo.eLife · 2021Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer.Nature communications · 2020Article
- A synthetic synaptic organizer protein restores glutamatergic neuronal circuits.Science (New York, N.Y.) · 2020Article
- Exciting Times: New Advances Towards Understanding the Regulation and Roles of Kainate Receptors.Neurochemical research · 2019Review
- The Reactive Plasticity of Hippocampal Ionotropic Glutamate Receptors in Animal Epilepsies.International journal of molecular sciences · 2019Review
- Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain.Nature communications · 2018Article
- The Role of Kainate Receptors in the Pathophysiology of Hypoxia-Induced Seizures in the Neonatal Mouse.Scientific reports · 2018Article
- N-glycan content modulates kainate receptor functional properties.The Journal of physiology · 2017Article
- Subunit-specific role for the amino-terminal domain of AMPA receptors in synaptic targeting.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.Cell reports · 2017Article
- Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Synaptic communication between neurons requires the precise localization of neurotransmitter receptors to the correct synapse type. Kainate-type glutamate receptors restrict synaptic localization that is determined by the afferent presynaptic connection. The mechanisms that govern this input-specific synaptic localization remain unclear. Here, we examine how subunit composition and specific subunit domains contribute to synaptic localization of kainate receptors. The cytoplasmic domain of the GluK2 low-affinity subunit stabilizes kainate receptors at synapses. In contrast, the extracellular domain of the GluK4/5 high-affinity subunit synergistically controls the synaptic specificity of kainate receptors through interaction with C1q-like proteins. Thus, the input-specific synaptic localization of the native kainate receptor complex involves two mechanisms that underlie specificity and stabilization of the receptor at synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.