ArticleScientific reports2016
Time-to-Progression of NSCLC from Early to Advanced Stages: An Analysis of data from SEER Registry and a Single Institute.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
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- Opinion paper: artificial intelligence as a clinical ally in lung cancer detection-the case for Gleamer's ChestView.Frontiers in oncology · 2025Article
- Health Economic Evaluation of Lung Cancer Screening Using a Diagnostic Blood Test: The Early Detection of Cancer of the Lung Scotland (ECLS).Current oncology (Toronto, Ont.) · 2024Article
- Smoking, Lung Cancer Stage, and Prognostic Factors-Findings from the National Lung Screening Trial.International journal of environmental research and public health · 2024Article
- Barriers to Timely Lung Cancer Care in Early Stage Non-Small Cell Lung Cancer and Impact on Patient Outcomes.Clinical lung cancer · 2024Article
- Impact of time-to-treatment on survival for early-stage non-small cell lung cancer in The Netherlands-a nationwide observational cohort study.Translational lung cancer research · 2023Article
- Advances in diagnosis and prediction for aggression of pure solid T1 lung cancer.Precision clinical medicine · 2023Article
- The Fast Growth and Quick Spread of Synchronous Tumors.Diagnostics (Basel, Switzerland) · 2023Article
- Clinical characteristics and prognosis of non-small cell lung cancer patients with liver metastasis: A population-based study.World journal of clinical cases · 2022Article
- Lung Cancer Stage Shift as a Result of COVID-19 Lockdowns in New York City, a Brief Report.Clinical lung cancer · 2022Article
- An inverse stage-shift model to estimate the excess mortality and health economic impact of delayed access to cancer services due to the COVID-19 pandemic.Asia-Pacific journal of clinical oncology · 2021Article
- Thoracic Surgeon Impressions of the Impact of the COVID-19 Pandemic on Lung Cancer Care-Lessons from the First Wave in Canada.Current oncology (Toronto, Ont.) · 2021Article
- Narrative review of lung cancer treatment at the time of COVID-19 pandemia: pitfall and issues.Translational lung cancer research · 2021Review
- Collateral effects of the coronavirus disease 2019 pandemic on lung cancer diagnosis in Korea.BMC cancer · 2020Article
- Low Galectin-3 Expression Level in Primary Tumors Is Associated with Metastasis in T1 Lung Adenocarcinoma.Journal of clinical medicine · 2020Article
- Microfluidics for studying metastatic patterns of lung cancer.Journal of nanobiotechnology · 2019Review
- Statistical analysis of mutant allele frequency level of circulating cell-free DNA and blood cells in healthy individuals.Scientific reports · 2017Article
- Reconsidering lung cancer screening: is biannual screening possible?Journal of thoracic disease · 2016Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The average time required for cancers to progress through stages can be reflected in the average age of the patients diagnosed at each stage of disease. To estimate the time it takes for non-small-cell lung cancer (NSCLC) to progress through different tumor, node and metastasis (TNM) stages and sizes, we compared the mean adjusted age of 45904 NSCLC patients with different stages and tumor sizes from Surveillance, Epidemiology and End Results (SEER) cancer registry database and our institute. Multiple-linear-regression models for age were generated adjusting for various factors. Caucasian, African-American and Asian patients with stage IA cancers were on average 0.8, 1.0 and 1.38 adjusted years younger, respectively, than those with stage IIIB cancers (p < 0.001). And these with T1a cancers were on average 0.84, 0.92 and 1.21 adjusted years younger, respectively, than patients with T3 cancers (p < 0.001). Patients with tumors measuring larger than 8 cm in diameter were on average 0.85 adjusted years older than these with tumors smaller than 1 cm (p < 0.001), with Caucasian demonstrating the shortest age span (0.79 years, P < 0.001). In conclusion, the time-to-progression of NSCLC from early to advanced stages varied among ethnicities, Caucasian patients demonstrating a more rapid progression nature of tumor than their African-American and Asian counterparts.
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