ArticleScientific reports2016
Evidence of extensive non-allelic gene conversion among LTR elements in the human genome.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- An ancient alpharetrovirus lineage in bats: Evolutionary insights and possible roles in reproduction.PLoS genetics · 2026Article
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- Low-input PacBio sequencing generates high-quality individual fly genomes and characterizes mutational processes.Nature communications · 2024Article
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- New insights into the evolution of human Y chromosome palindromes through mutation and gene conversion.Human molecular genetics · 2021Article
- Gene Conversion amongstGenes · 2021Article
- What Can Long Terminal Repeats Tell Us About the Age of LTR Retrotransposons, Gene Conversion and Ectopic Recombination?Frontiers in plant science · 2020Article
- Review
- Endogenous Retroviruses Activity as a Molecular Signature of Neurodevelopmental Disorders.International journal of molecular sciences · 2019Review
- The Role of Gene Conversion between Transposable Elements in Rewiring Regulatory Networks.Genome biology and evolution · 2019Review
- Retrovirus insertion site analysis of LGL leukemia patient genomes.BMC medical genomics · 2019Article
- Origins and evolutionary consequences of ancient endogenous retroviruses.Nature reviews. Microbiology · 2019Review
- A computational framework to assess genome-wide distribution of polymorphic human endogenous retrovirus-K In human populations.PLoS computational biology · 2019Article
- Article
- LTR Retrotransposons Show Low Levels of Unequal Recombination and High Rates of Intraelement Gene Conversion in Large Plant Genomes.Genome biology and evolution · 2017Article
- Frequent nonallelic gene conversion on the human lineage and its effect on the divergence of gene duplicates.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Y chromosomes of the great apes.Human genetics · 2017Review
- Y chromosome palindromes and gene conversion.Human genetics · 2017Review
- Patterns of Inter-Chromosomal Gene Conversion on the Male-Specific Region of the Human Y Chromosome.Frontiers in genetics · 2017Review
- Friends-Enemies: Endogenous Retroviruses Are Major Transcriptional Regulators of Human DNA.Frontiers in chemistry · 2017Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long Terminal Repeats (LTRs) are nearly identical DNA sequences found at either end of Human Endogenous Retroviruses (HERVs). The high sequence similarity that exists among different LTRs suggests they could be substrate of ectopic gene conversion events. To understand the extent to which gene conversion occurs and to gain new insights into the evolutionary history of these elements in humans, we performed an intra-species phylogenetic study of 52 LTRs on different unrelated Y chromosomes. From this analysis, we obtained direct evidence that demonstrates the occurrence of ectopic gene conversion in several LTRs, with donor sequences located on both sex chromosomes and autosomes. We also found that some of these elements are characterized by an extremely high density of polymorphisms, showing one of the highest nucleotide diversities in the human genome, as well as a complex patchwork of sequences derived from different LTRs. Finally, we highlighted the limits of current short-read NGS studies in the analysis of genetic diversity of the LTRs in the human genome. In conclusion, our comparative re-sequencing analysis revealed that ectopic gene conversion is a common event in the evolution of LTR elements, suggesting complex genetic links among LTRs from different chromosomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.