Evidence map›Paper›PMID 27345945›Full record

ArticlePhysical biology2016

Effects of 3D geometries on cellular gradient sensing and polarization.

Fabian Spill, Vivi Andasari, Michael Mak, Roger D Kamm, Muhammad H Zaman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Sensing the shape of a cell with reaction diffusion and energy minimization.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  2. Review
  3. Review
  4. Modern perspectives on near-equilibrium analysis of Turing systems.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021
    Review
  5. Article
  6. Engineering fiber anisotropy within natural collagen hydrogels.American journal of physiology. Cell physiology · 2021
    Review
  7. Article
  8. Turing Patterning in Stratified Domains.Bulletin of mathematical biology · 2020
    Article
  9. Article
  10. Mechanical and Systems Biology of Cancer.Computational and structural biotechnology journal · 2018
    Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fabian SpillDepartment of Biomedical Engineering, Boston University, 44 Cummington Street, Boston MA 02215, USA.
Vivi AndasariDepartment of Biomedical Engineering, Boston University, 44 Cummington Street, Boston MA 02215, USA.
Michael MakDepartment of Biomedical Engineering, Boston University, 44 Cummington Street, Boston MA 02215, USA.
Roger D KammDepartment of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Muhammad H ZamanDepartment of Biomedical Engineering, Boston University, 44 Cummington Street, Boston MA 02215, USA.

Funding

Modeling bi-directional signaling and cytoskeletal dynamics in 3D cell migrationsU01CA177799 · NCI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI GERTLER, FRANK B, KAMM, ROGER D · 2013 to 2017
$3.0M
NCI NIH HHS U01 CA177799
6 · The paper itself

Abstract

During cell migration, cells become polarized, change their shape, and move in response to various internal and external cues. Cell polarization is defined through the spatio-temporal organization of molecules such as PI3K or small GTPases, and is determined by intracellular signaling networks. It results in directional forces through actin polymerization and myosin contractions. Many existing mathematical models of cell polarization are formulated in terms of reaction-diffusion systems of interacting molecules, and are often defined in one or two spatial dimensions. In this paper, we introduce a 3D reaction-diffusion model of interacting molecules in a single cell, and find that cell geometry has an important role affecting the capability of a cell to polarize, or change polarization when an external signal changes direction. Our results suggest a geometrical argument why more roundish cells can repolarize more effectively than cells which are elongated along the direction of the original stimulus, and thus enable roundish cells to turn faster, as has been observed in experiments. On the other hand, elongated cells preferentially polarize along their main axis even when a gradient stimulus appears from another direction. Furthermore, our 3D model can accurately capture the effect of binding and unbinding of important regulators of cell polarization to and from the cell membrane. This spatial separation of membrane and cytosol, not possible to capture in 1D or 2D models, leads to marked differences of our model from comparable lower-dimensional models.

Indexed as

Cell PolarityModels, BiologicalCell MembraneCytosolDiffusion

Identifiers

PMID27345945
PMCPMC4963243

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.