ArticleScientific reports2016
Let-7i-5p represses brite adipocyte function in mice and humans.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Thermogenic Differentiation of Human Adipocyte Precursors in Culture: A Systematic Review.Cells · 2025Pooled it
- New Mediators in the Crosstalk between Different Adipose Tissues.International journal of molecular sciences · 2024Pooled it
- Male obesity causes adipose mitochondrial dysfunction in FNature communications · 2026Article
- Impact of Western diet on milk miRNAs and target genes in offspring adipose tissue: modulation by betaine during suckling.Obesity (Silver Spring, Md.) · 2025Article
- Pulling the trigger: Noncoding RNAs in white adipose tissue browning.Reviews in endocrine & metabolic disorders · 2024Review
- Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases.Nutrition & metabolism · 2022Review
- Extracellular vesicles derived from tumour cells as a trigger of energy crisis in the skeletal muscle.Journal of cachexia, sarcopenia and muscle · 2022Article
- Regulation of Adipose Thermogenesis and its Critical Role in Glucose and Lipid Metabolism.International journal of biological sciences · 2022Review
- Tissue and circulating microRNAs as biomarkers of response to obesity treatment strategies.Journal of endocrinological investigation · 2021Review
- AGO HITS-CLIP reveals distinct miRNA regulation of white and brown adipose tissue identity.Genes & development · 2021Article
- Genome-wide identification and characterization of perirenal adipose tissue microRNAs in rabbits fed a high-fat diet.Bioscience reports · 2021Article
- Let-7i-5p enhances cell proliferation, migration and invasion of ccRCC by targeting HABP4.BMC urology · 2021Article
- MicroRNAs in Colon Tissue of Pediatric Ulcerative Pancolitis Patients Allow Detection and Prognostic Stratification.Journal of clinical medicine · 2021Article
- microRNA let-7i-5p mediates the relationship between muscle fat infiltration and neck pain disability following motor vehicle collision: a preliminary study.Scientific reports · 2021Article
- Epigenetic Regulators of White Adipocyte Browning.Epigenomes · 2021Review
- The Yin and Yang function of microRNAs in insulin signalling and cancer.RNA biology · 2021Review
- Review
- Epigenetic contribution to obesity.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Review
- The role of microRNA-23b-5p in regulating brown adipogenesis and thermogenic program.Endocrine connections · 2020Article
- Identification of Differentially Expressed MicroRNAs and Their Potential Target Genes in Adipose Tissue from Pigs with Highly Divergent Backfat Thickness.Animals : an open access journal from MDPI · 2020Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In response to cold or β3-adrenoreceptor stimulation brown adipose tissue (BAT) promotes non-shivering thermogenesis, leading to energy dissipation. BAT has long been thought to be absent or scarce in adult humans. The recent discovery of thermogenic brite/beige adipocytes has opened the way to development of novel innovative strategies to combat overweight/obesity and associated diseases. Thus it is of great interest to identify regulatory factors that govern the brite adipogenic program. Here, we carried out global microRNA (miRNA) expression profiling on human adipocytes to identify miRNAs that are regulated upon the conversion from white to brite adipocytes. Among the miRNAs that were differentially expressed, we found that Let-7i-5p was down regulated in brite adipocytes. A detailed analysis of the Let-7i-5p levels showed an inverse expression of UCP1 in murine and human brite adipocytes both in vivo and in vitro. Functional studies with Let-7i-5p mimic in human brite adipocytes in vitro revealed a decrease in the expression of UCP1 and in the oxygen consumption rate. Moreover, the Let-7i-5p mimic when injected into murine sub-cutaneous white adipose tissue inhibited partially β3-adrenergic activation of the browning process. These results suggest that the miRNAs Let-7i-5p participates in the recruitment and the function of brite adipocytes.
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Registered trials
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