Evidence map›Paper›PMID 27345402›Full record

ArticleOncogene2017

Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis.

Z Deng, Y Rong, Y Teng, X Zhuang, A Samykutty, J Mu, L Zhang, P Cao, J Yan, D Miller and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed, 3 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

141 citing papers in PubMed, 3 syntheses or guidelines pooled it, 205 citations in OpenAlex.

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  20. MDSC: a new potential breakthrough in CAR-T therapy for solid tumors.Cell communication and signaling : CCS · 2024
    Review

81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Z DengJames Graham Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.
Y RongJames Graham Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.
Y TengJames Graham Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.
X ZhuangJames Graham Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.
A SamykuttyJames Graham Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.
J MuJames Graham Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.
L ZhangJames Graham Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.
P CaoJames Graham Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.
J YanJames Graham Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.
D MillerJames Graham Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.
H-G ZhangJames Graham Brown Cancer Center, Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.
University of Louisville · USLouisville VA Medical Center · US

Funding

Plant exosomes non-coding RNA-mediated anti-inflammatory mechanismsR01AT008617 · NCCIH · UNIVERSITY OF LOUISVILLE · PI HUANG-GE ZHANG · 2016 to 2026
$5.7M
Fruit exosome-like particles for therapeutic delivery of extracellular miRNAsUH3TR000875 · NCATS · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2015 to 2017
$2.7M
Fruit exosome-like particles for therapeutic delivery of extracellular miRNAsUH2TR000875 · NCATS · UNIVERSITY OF LOUISVILLE · PI GUO, PEIXUAN, ZHANG, HUANG-GE · 2013 to 2014
$867k
Intramural VA VA999999NCATS NIH HHS UH2 TR000875NCATS NIH HHS UH3 TR000875NCCIH NIH HHS R01 AT008617
6 · The paper itself

Abstract

Acquired resistance to chemotherapy remains a major stumbling block in cancer treatment. Chronic inflammation has a crucial role in induction of chemoresistance and results, in part, from the induction and expansion of inflammatory cells that include myeloid-derived suppressor cells (MDSCs) and IL-13

Indexed as

AnimalsAntibiotics, AntineoplasticBreast NeoplasmsCell Line, TumorDoxorubicinExosomesFemaleHumansLung NeoplasmsMiceMice, Inbred BALB CMice, Inbred C57BLMicroRNAsMyeloid-Derived Suppressor CellsNeoplasm MetastasisAntibiotics, AntineoplasticDoxorubicinMicroRNAsMIRN126 microRNA, human

Identifiers

PMID27345402
PMCPMC5419051
OpenAlexW2461221680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.